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Titolo:
Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in squamous cell carcinomas of lung
Autore:
Xue, Q; Sano, T; Kashiwabara, K; Oyama, T; Nakajima, T;
Indirizzi:
Gunma Univ, Sch Med, Dept Pathol 2, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 2, Maebashi, Gumma 3718511, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 3, volume: 92, anno: 2001,
pagine: 285 - 292
SICI:
0910-5050(200103)92:3<285:AEOPPP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; RETINOBLASTOMA SUSCEPTIBILITY GENE; WILD-TYPE P53; PROTEIN EXPRESSION; IMMUNOHISTOCHEMICAL ANALYSIS; POOR-PROGNOSIS; HUMAN CANCERS; INACTIVATION; RB; P16(INK4A);
Keywords:
pRB pathway; p53 pathway; squamous cell carcinoma; lung; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Nakajima, T Gunma Univ, Sch Med, Dept Pathol 2, 3-39-22 Showa Machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-22 Showa Machi Maebashi Gumma Japan 3718511 an
Citazione:
Q. Xue et al., "Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in squamous cell carcinomas of lung", JPN J CANC, 92(3), 2001, pp. 285-292

Abstract

Expression of cell cycle regulatory proteins in both the RE and p53 pathways was investigated in 50 cases of squamous cell carcinoma (SCC) of the lung using immunohistochemical techniques. Abnormality of pRb and p16 expression was seen at the frequencies of 16% and 78%, respectively, and appeared to be in a reciprocal relationship. On the other hand, strong and diffuse p53 immunoreactivity was seen in 60% of SCCs, MDM2 and p14ARF expressions were each observed in about half of the cases of SCC and were not significantly associated with strong p53 immunoreactivity, Statistical analysis revealed that p14ARF expression was significantly correlated with both p16 and MDM2 expression. Moreover, strong p53 expression was not correlated with the expression of p21, In comparing clinicopathological status with the immunohistochemical results, lack of p16 immunoreactivity was observed in the elderly group (over 65 years) as compared with the younger group (less than 65 years), Strong p53 expression was frequently observed in higher stages of SCC, with the developing tumor located in the central field of the lung. Similarly, the frequency of p14ARF expression was high in centrally developed SCC, but low in SCC developed in the periphery. These results suggest that disruption of the RE and p53 pathways is a frequent el ent in SCC, and that abnormal expression of p16 and p53 plays a more critical role than that of pRB, p14ARF and MDM2 in the development of SCC of the lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 07:39:59