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Titolo:
The methylenetetrahydrofolate reductase gene polymorphism in Koreans with coronary artery disease
Autore:
Kim, CH; Hwang, KY; Choi, TM; Shin, WY; Hong, SY;
Indirizzi:
Soonchunhyang Univ, Chunan Hosp, Dept Internal Med, Chunan 330100, Chungnam, South Korea Soonchunhyang Univ Chunan Chungnam South Korea 330100 ungnam, South Korea Soonchunhyang Univ, Sch Med, Dept Prevent Med, Chungnam, South Korea Soonchunhyang Univ Chungnam South Korea vent Med, Chungnam, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 13 - 17
SICI:
0167-5273(200103)78:1<13:TMRGPI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-DISEASE; RISK FACTOR; COMMON MUTATION; MYOCARDIAL-INFARCTION; TOTAL HOMOCYSTEINE; FOLATE;
Keywords:
coronary artery disease; homocysteine; methylenetetrahydrofolate reductase; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, CH Soonchunhyang Univ, Chunan Hosp, Dept Internal Med, 23-20 Bongmyung Dong, Chunan 330100, Chungnam, South Korea Soonchunhyang Univ 23-20 Bongmyung Dong Chunan Chungnam South Korea 330100
Citazione:
C.H. Kim et al., "The methylenetetrahydrofolate reductase gene polymorphism in Koreans with coronary artery disease", INT J CARD, 78(1), 2001, pp. 13-17

Abstract

Hyperhomocysteinemia is a known risk factor of cardiovascular diseases. Methylenetetrahydrofolate reductase (MTHFR), involved in folate-dependant metabolism, is associated with homocysteine levels. We studied the associations among MTHFR genotypes, coronary artery disease (CAD), and homocysteine levels in 85 patients with CAD and 152 healthy subjects. The MTHFR genotypes and plasma homocysteine levels were determined. No significant difference in mutation of the MTHFR gene between two groups was observed (P>0.05). While the homozygous mutant genotype (V/V) had the highest homocysteine levels compared to wild (A/A) and heterozygous mutant (A/V) genotypes. there were no significant differences in homocysteine levels among the MTHFR genotype groups. Homocysteine was significantly and inversely related to folate levels, the significant association in V/V genotype (beta coefficient= - 1.954,P=0.04). Our data suggested that MTHFR polymorphism was not associated with homocysteine levels, implying no association between gene polymorphism and CAD in Koreans. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:48:16