Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat
Autore:
Uknis, AB; DeLa Cadena, RA; Janardham, R; Sartor, RB; Whalley, ET; Colman, RW;
Indirizzi:
Temple Univ, Sch Med, Dept Med, Sol Sherry Thrombosis Res Ctr, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 Res Ctr, Philadelphia, PA 19140 USA Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19140 USA Temple Univ Philadelphia PA USA 19140 Physiol, Philadelphia, PA 19140 USA Univ N Carolina, Dept Digest Dis & Nutr, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Nutr, Chapel Hill, NC 27599 USA Biogen Inc, Cambridge Ctr 14, Cambridge, MA 02142 USA Biogen Inc Cambridge MA USA 02142 mbridge Ctr 14, Cambridge, MA 02142 USA
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 3, volume: 50, anno: 2001,
pagine: 149 - 155
SICI:
1023-3830(200103)50:3<149:BRAT2A>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT KININOGEN; CONTACT SYSTEM ACTIVATION; PLASMA KALLIKREIN; ENDOTHELIAL-CELLS; HUMAN-NEUTROPHILS; HAGEMAN-FACTOR; HEREDITARY ANGIOEDEMA; SYNOVIAL FIBROBLASTS; ENDOTOXIN-SHOCK; B-1;
Keywords:
peptidoglycan-polysaccharide arthritis model bradykinin; plasma prekallikrein; high molecular weight kininogen; interleukin-1 beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Colman, RW Temple Univ, Sch Med, Dept Med, Sol Sherry Thrombosis Res Ctr, 3400 N Broad St, Philadelphia, PA 19140 USA Temple Univ 3400 N Broad St Philadelphia PA USA 19140 19140 USA
Citazione:
A.B. Uknis et al., "Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat", INFLAMM RES, 50(3), 2001, pp. 149-155

Abstract

Objective and Design:We studied the ability of bradykinin (BK) receptor antagonists type 1 and 2 (B1-RA, B2-RA) to prevent acute inflammation. Material: A peptidoglycan-polysaccharide (PG-APS)-induced model of arthritis in the Lewis rat was analyzed. Treatment: Four groups of animals were studied for 5 days. Treatment was administered subcutaneously (s.c.) 1 mg/kg every 12 h. Group I received PG-APS and was treated with the B2-RA, CP-0597 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-NChg-Arg). Group II received PG-APS and was treated with a combined B1 and B2-RA, B9430 (DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg). Group III received PG-APS and albumin control. Group IV received albumin control. Methods: Joint diameter, liver weight, hematocrit, white blood count and plasma concentrations of prekallikrein, high molecular weight kininogen, HK and IL-1 beta were measured. Groups were compared by ANOVA. Results: Acute arthritis and hepatomegaly were attenuated in the B2-RA-treated animals (p<0.05). Weight loss was more pronounced in the B1/B2-RA-treated animals. Anemia induced by PG-APS was prevented by B2-RA and B1/B2-RA treatment (p<0.001). A marked decrease in plasma HK to 64% of normal was found in the disease-untreated animals, which was completely normalized by BZ-RA treatment and partially attenuated by the B1/B2-RA (78 %). The decrease in plasma prekallikrein levels was prevented by combined B1/B2-RA treatment(p<0.05). Finally, elevated plasma IL-1<beta> levels were lowered by B1/B2-RA treatment and were below detection limits with the B2-RA treatment. Conclusions: These results indicate that the systemic inflammation is due in part to BK generation which can be blocked by B2-RA, while inhibiting the B1 receptor prevents an antiinflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:45:46