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Titolo:
Follicular development and hormone concentrations following recombinant FSH administration for anovulation associated with polycystic ovarian syndrome: prospective, randomized comparison between low-dose step-up and modifiedstep-down regimens
Autore:
Balasch, J; Fabregues, F; Creus, M; Puerto, B; Penarrubia, J; Vanrell, JA;
Indirizzi:
Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Inst Clin Gynecol Obstet & Neonatol, Barcelona, Spain Univ Barcelona Barcelona Spain ecol Obstet & Neonatol, Barcelona, Spain
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 4, volume: 16, anno: 2001,
pagine: 652 - 656
SICI:
0268-1161(200104)16:4<652:FDAHCF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; STIMULATING-HORMONE; OVULATION INDUCTION; HYPOGONADOTROPIC HYPOGONADISM; LUTEINIZING-HORMONE; WOMEN; GONADOTROPINS; INFERTILITY; THERAPY; RESISTANT;
Keywords:
low-dose FSW; ovulation induction; polycystic ovary; recombinant FSH; step-down regimen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Balasch, J Hosp Clin, Inst Gynecol Obstet & Neonatol, C Casanova 143, Barcelona 08036, Spain Hosp Clin C Casanova 143 Barcelona Spain 08036 na 08036, Spain
Citazione:
J. Balasch et al., "Follicular development and hormone concentrations following recombinant FSH administration for anovulation associated with polycystic ovarian syndrome: prospective, randomized comparison between low-dose step-up and modifiedstep-down regimens", HUM REPR, 16(4), 2001, pp. 652-656

Abstract

The present study compared ovarian performance and hormone concentrations,after ovulation induction, in polycystic ovarian syndrome (PCOS) patients,using recombinant human FSH (rhFSH) in low-dose step-up and modified step-down regimens. Twenty-six women with clomiphene citrate-resistant chronic anovulatory infertility were treated with rhFSH in two consecutive cycles according to two different low-dose regimens: (i) the classic chronic low-dose step-up protocol, the starting dose being 75 IU; (ii) a modified step-down protocol where the starting dose was 300 IU followed by 3 days free of treatment, then rhFSH 75 IU daily was given and stepwise dose increments wereperformed exactly the same as in the step-up method. Each woman received both treatment approaches, in a randomized order, with an interval of greater than or equal to1 month between treatments. The total number of folliclesthat were >10, >14 and >17 mm in diameter on the day of human chorionic gonadotrophin (HCG) administration, and thus cycles with HCG cancelled, were significantly increased with the step-up approach. The total number of rhFSH ampoules tended to be higher with the step-down schedule despite the factthat both the mean duration of treatment and the threshold dose were similar with the two low-dose approaches. A physiological step-down approach forovulation induction in PCOS patients may be more appropriate in order to avoid multifollicular cycles than the step-up approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:06:31