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Titolo:
Poor responder-high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols
Autore:
Neulen, J; Wenzel, D; Hornig, C; Wunsch, E; Weissenborn, U; Grunwald, K; Buttner, R; Weich, H;
Indirizzi:
Rhein Westfal TH Aachen, Dept Gynecol Endocrinol & Reprod Med, Univ Clin, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Receptor Ligand Technol GmBH RELIATech, Braunschweig, Germany Receptor Ligand Technol GmBH RELIATech Braunschweig Germany ig, Germany Rhein Westfal TH Aachen, Dept Pathol, Univ Clin, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 4, volume: 16, anno: 2001,
pagine: 621 - 626
SICI:
0268-1161(200104)16:4<621:PRRTIO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GRANULOSA-CELLS; CORPUS-LUTEUM FORMATION; HYPERSTIMULATION SYNDROME; PERMEABILITY FACTOR; INVITRO FERTILIZATION; FOLLICULAR-FLUID; TYROSINE KINASE; FACTOR VEGF; IN-VITRO; LEVELS CORRELATE;
Keywords:
gonadotrophin therapy; ovarian function; sVEGFR-1; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Neulen, J Rhein Westfal TH Aachen, Dept Gynecol Endocrinol & Reprod Med, Univ Clin, Pauwelsstr 30, D-52074 Aachen, Germany Rhein Westfal TH Aachen Pauwelsstr 30 Aachen Germany D-52074 ny
Citazione:
J. Neulen et al., "Poor responder-high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols", HUM REPR, 16(4), 2001, pp. 621-626

Abstract

This study was designed to detect vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-1) in follicular fluid specimens and to evaluate the importance of sVEGFR-1 with respect to ovarian response to gonadotrophin stimulation. A total of 69 patients was treated for IVF with recombinant human follicle stimulating hormone (FSH), Concentrations of VEGF and sVEGFR-1 were quantified in follicular fluids from oocyte retrievals, Patients were designated to three groups with respect to the number of harvested oocytes: group A, 1-5 oocytes; group B, 6-10 oocytes; group C, >10 oocytes, In group A, 1133 +/- 870 pg VEGF/ml follicular fluid per oocyte were quantified, in group B 426 +/- 262 pg VEGF/ml per oocyte, and in group C 274+/- 179 pg VEGF/ml per oocyte, Soluble VEGFR-1 concentrations resulted in 1200 +/- 523 pg/ml follicular fluid per oocyte in group A, 255 +/- 193 pg/ml per oocyte in group B, and 79 +/- 69 pg/ml per oocyte in group C, No freesVEGFR-1 could be detected in any follicular fluid. An index to estimate the biological activity of VEGF by dividing VEGF/sVEGFR-1 revealed an increasing availability of VEGF with higher ovarian response to gonadotrophin therapy. In group A this index was 1.03, in group B 1.71, and in group C 3.21,A delicate balance between VEGF and sVEGFR-1 is necessary to allow an adequate ovarian reaction to gonadotrophin therapy. Excess of bio-active VEGF increases the risk for ovarian hyperstimulation syndrome. Excess of sVEGFR-1results in poor response and goes in parallel with reduced chances for conception.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:30:06