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Titolo:
Detection and characterization of human herpesvirus-8-infected cells in bone marrow biopsies of human immunodeficiency virus-positive patients
Autore:
Meggetto, F; Cesarman, E; Mourey, L; Massip, P; Delsol, G; Brousset, P;
Indirizzi:
CHU Purpan, Anat Pathol Lab, F-31059 Toulouse, France CHU Purpan Toulouse France F-31059 Pathol Lab, F-31059 Toulouse, France CHU Purpan, Dept Infect Dis, F-31059 Toulouse, France CHU Purpan Toulouse France F-31059 Infect Dis, F-31059 Toulouse, France Cornell Univ, Weill Med Coll, Dept Pathol, New York, NY USA Cornell Univ New York NY USA ill Med Coll, Dept Pathol, New York, NY USA
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 3, volume: 32, anno: 2001,
pagine: 288 - 291
SICI:
0046-8177(200103)32:3<288:DACOHH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; MULTICENTRIC CASTLEMANS-DISEASE; PRIMARY EFFUSION LYMPHOMA; KAPOSIS-SARCOMA; MULTIPLE-MYELOMA; DENDRITIC CELLS; DNA-SEQUENCES; KSHV; HUMAN-HERPESVIRUS-8; EXPRESSION;
Keywords:
human herpesvirus-8; Kaposi sarcoma herpesvirus; bone marrow; viral interleukin-6; acquired immunodeficiency syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Brousset, P CHU Purpan, Anat Pathol Lab, Pl Dr Baylac, F-31059 Toulouse, France CHU Purpan Pl Dr Baylac Toulouse France F-31059 louse, France
Citazione:
F. Meggetto et al., "Detection and characterization of human herpesvirus-8-infected cells in bone marrow biopsies of human immunodeficiency virus-positive patients", HUMAN PATH, 32(3), 2001, pp. 288-291

Abstract

We studied 15 bone marrow biopsy specimens from patients with human immunodeficiency virus infection for detection of Kaposi sarcoma herpesvirus (KSHV/HHV-8) DNA sequences by a very sensitive and specific polymerase chain reaction (PCR) assay (with 3 different sets of primers). In addition, we usedimmunohistochemistry with anti-viral interleukin-6 (VIL-6) and anti-latentnuclear antigen-1 (LNA-1) antibodies to localize the infected cells on tissue sections. Among the 15 samples, 6 had positive PCR results with the 3 sets of primers (orf26, orf72, orf75), Interestingly, in 2 of these 6 patients (both with Kaposi sarcoma) vIL-6 and LNA-1 were detected in mononuclear lymphoid cells but not in stromal cells of the bone marrow. The detection of vIL-6-positive lymphoid cells in bone marrow suggests a homing for HHV-8-infected elements in this: tissue. The local release of vIL-6 may play somerole in the plasmacytosis observed in bone marrow in the acquired immunodeficiency syndrome. HUM PATHOL 32:288-291. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:35:40