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Titolo:
Characterization of publicly available SNPs in the Korean population
Autore:
Lee, SG; Hong, S; Yoon, Y; Yang, I; Song, K;
Indirizzi:
Univ Ulsan, Coll Med, Dept Biochem, Seoul 138736, South Korea Univ Ulsan Seoul South Korea 138736 t Biochem, Seoul 138736, South Korea Asan Inst Life Sci, Seoul, South Korea Asan Inst Life Sci Seoul South Korea Inst Life Sci, Seoul, South Korea
Titolo Testata:
HUMAN MUTATION
fascicolo: 4, volume: 17, anno: 2001,
pagine: 281 - 284
SICI:
1059-7794(2001)17:4<281:COPASI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFICATION; SEQUENCE; MARKERS; LINKAGE; GENOME;
Keywords:
SNPs; publicly available; allele frequency; ethnic variation; comparative sequencing; Korean;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Song, K Univ Ulsan, Coll Med, Dept Biochem, 388-1 Poongnap-Dong, Seoul 138736, South Korea Univ Ulsan 388-1 Poongnap-Dong Seoul South Korea 138736 uth Korea
Citazione:
S.G. Lee et al., "Characterization of publicly available SNPs in the Korean population", HUM MUTAT, 17(4), 2001, pp. 281-284

Abstract

Single-nucleotide polymorphisms (SNPs) are the most abundant form of genetic variations and have a great potential for mapping studies of complex genetic traits. Currently a great deal of effort is invested in the identification of SNPs, and a large volume of data is already available through public databases (NCBI, NCI, WICGR, HGBASE). For an association mapping study, SNP allele frequencies in the population are critical. As an initial step toward construction of an SNP database of the Korean population, we have determined the allele frequencies of 300 cSNPs selected from the public database in 24 individuals. Among the tested markers, approximately 23% did not show polymorphism in the population. The results suggest that the ethnic and population based differences should be considered in the selection of SNPs for the study of complex diseases with association mapping methods. Hum Mutat 17:281-284, 2001, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:40:48