Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effect of nitric oxide production by sinusoidal endothelial cells on preservation injury during cold ischemia
Autore:
Oishi, A; Inagaki, M; Sadamori, H; Yagi, T; Tanaka, N;
Indirizzi:
Okayama Univ, Sch Med, Dept Surg 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Surg 1, Okayama 7008558, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 3, volume: 19, anno: 2001,
pagine: 325 - 335
SICI:
1386-6346(200103)19:3<325:TEONOP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXING FACTOR; UW SOLUTION; RAT LIVERS; REPERFUSION; INHIBITION; ALLOGRAFTS; APOPTOSIS;
Keywords:
cell injury; nitric oxide inhibitor; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Oishi, A Okayama Univ, Sch Med, Dept Surg 1, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
A. Oishi et al., "The effect of nitric oxide production by sinusoidal endothelial cells on preservation injury during cold ischemia", HEPATOL RES, 19(3), 2001, pp. 325-335

Abstract

Multifactorial elements are responsible for preservation and reperfusion injury in liver allografts. Sinusoidal endothelial cells (SECs) are a primary target of cold preservation injury of the liver. We examined the correlation between nitric oxide (NO) production by SECs and their injury during cold preservation. SECs were isolated from rat livers and preserved in eitherEuro-Collins (EC) or University of Wisconsin (UW) solution. Injury to the SECs was more severe when preserved in the EC solution than in the UW solution during cold ischemia. In addition, NO production by SECs was found to be proportionate to the cell injury. Cell viability was not improved by the addition of NO inhibitor, L-NMMA. Further, NO inhibitor was detrimental to the SECs in a 24-h preservation in UW solution. LDH release by SECs preserved in UW solution supplemented with L-NMMA was 11.10 +/- 2.03 IU/l, while that in UW solution alone was 3.70 +/- 0.70 IU/l (P < 0.01). Together, our results suggest that NO protects SECs during cold preservation and that NO from SECs may have beneficial effects on the liver during cold ischemia. (C)2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:03:06