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Titolo:
Styrene-induced hearing loss: a membrane insult
Autore:
Campo, P; Lataye, R; Loquet, G; Bonnet, P;
Indirizzi:
Inst Natl Rech & Secur, Lab Neurotoxicite, F-54501 Vandoeuvre Nancy, France Inst Natl Rech & Secur Vandoeuvre Nancy France F-54501 vre Nancy, France
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 154, anno: 2001,
pagine: 170 - 180
SICI:
0378-5955(200104)154:1-2<170:SHLAMI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT COCHLEA; EXPOSURE; TOLUENE; NOISE; TRICHLOROETHYLENE; OTOTOXICITY; SOLVENTS; ORGAN; CORTI; CELLS;
Keywords:
styrene; solvent; ototoxicity; membrane; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Campo, P Inst Natl Rech & Secur, Lab Neurotoxicite, POB 27, F-54501 Vandoeuvre Nancy, France Inst Natl Rech & Secur POB 27 Vandoeuvre Nancy France F-54501 ce
Citazione:
P. Campo et al., "Styrene-induced hearing loss: a membrane insult", HEARING RES, 154(1-2), 2001, pp. 170-180

Abstract

Styrene is an aromatic solvent widely used as a precursor for polystyrene plastics in many factories which produce glass-reinforced plastic. This solvent has been shown to disrupt the auditory system in both humans and animals. In order to study the sequence of events which could explain the cochlear impairments. a time course experiment was carried out with 6-month-old rats. Male LongEvans rats were exposed to 1000 ppm styrene for 6 h/day, 5 days/week, for either 1, 2, 3, or 4 consecutive weeks. Auditory function was tested by recording the near field evoked potentials from the inferior colliculus, and histological analyses of the cochleae were performed with lightand transmission electron microscopy. The electrophysiological results support a toxic mid-frequency process which keeps worsening even after the endof the exposure. The histological findings demonstrate that supporting cells are the first targets of the solvent. Then. the outer hair cells of the third row (OHC3) are disrupted, followed successively by OHC2 and OHC1 fromthe basal (20 kHz) to the upper turn (4 kHz) of the cochlea. Basically, the disorganization of the membranous structures could be the starting point for the cochlear injury induced by styrene. This paper presents a hypothesis that the accumulation of K+ in the spaces of Nuel underlies the toxic effects of styrene. (C) 2001 published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 02:50:50