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Titolo:
NMDA receptor blockage protects against permanent noise-induced hearing loss but not its potentiation by carbon monoxide
Autore:
Chen, GD; Kong, J; Reinhard, K; Fechter, LD;
Indirizzi:
Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 arm, Oklahoma City, OK 73190 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 154, anno: 2001,
pagine: 108 - 115
SICI:
0378-5955(200104)154:1-2<108:NRBPAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; METHYL-D-ASPARTATE; POTASSIUM-INDUCED RELEASE; ISCHEMIC BRAIN-DAMAGE; OUTER HAIR CELL; ACOUSTIC OVERSTIMULATION; GLUTAMATE NEUROTOXICITY; INNER-EAR; PATHO-PHYSIOLOGY; MK-801 PROTECTS;
Keywords:
NMDA receptor antagonist; MK-801-stereo isomers; noise-induced hearing loss; carbon monoxide ototoxicity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, GD Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, 1110 N Stonewall, Oklahoma City, OK 73190 USA Univ Oklahoma 1110 N Stonewall Oklahoma City OK USA 73190 190 USA
Citazione:
G.D. Chen et al., "NMDA receptor blockage protects against permanent noise-induced hearing loss but not its potentiation by carbon monoxide", HEARING RES, 154(1-2), 2001, pp. 108-115

Abstract

While a clear role has been proposed for glutamate as a putative neurotransmitter at the inner hair cell type I spiral ganglion cell synapse, the possible role of excessive glutamate release in cochlear impairment and of NMDA receptors in such a process is uncertain. The present study compares the protective effects of (+)-MK-801, an NMDA receptor antagonist, and the relatively inactive isomer (-)-MK-801 against permanent noise-induced hearing loss (NIHL). The study also asks whether (+)-MK-801 can protect against the NIHL potentiation by carbon monoxide (CO). Rats (n = 6) were exposed to 100-dB, 13.6-kHz octave-band noise for 2 h after receiving injection of (+)-MK-801 hydrogen maleate (1 mg/kg), (-)-MK-801 hydrogen maleate (1 mg/kg), or saline. Other groups of animals were exposed to the combination of noise and CO (1200 ppm) after receiving (+)-MK-801 or saline. Additional subjects received (+)-MK-801. saline or CO exposure alone. Compound action potential (CAP) threshold sensitivities were compared 4 weeks after the exposures. The results show significant protection by (+)-MK-801 against the permanent CAP threshold elevation induced bq noise alone. but no protective effect of (-)-MK-801. (+)-MK-801 produced limited protection against threshold shiftsinduced by the combination of noise and CO. Outer hair cell (OHC) loss wasnot protected by (+)-MK-801 administration. The data suggest that NMDA receptor stimulation may play a role in NIHL resulting from fairly mild noise exposure. The data do not support a role for NMDA receptor stimulation in the potentiation of NIHL that results from simultaneous exposure to CO and noise. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 09:20:55