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Titolo:
Anemone repair proteins as a potential therapeutic agent for vertebrate hair cells: facilitated recovery of the lateral line of blind cave fish
Autore:
Repass, JJ; Watson, GM;
Indirizzi:
Univ SW Louisiana, Dept Biol, Lafayette, LA 70504 USA Univ SW Louisiana Lafayette LA USA 70504 pt Biol, Lafayette, LA 70504 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 154, anno: 2001,
pagine: 98 - 107
SICI:
0378-5955(200104)154:1-2<98:ARPAAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANOPTICHTHYS-JORDANI CHARACIDAE; ANGELFISH PTEROPHYLLUM-EIMEKEI; FLOW FIELD ANALYSIS; MATHEMATICAL-DESCRIPTION; PLANE SURFACE; SEA-ANEMONES; SYSTEM; TRANSDUCTION; REGENERATION; PERFORMANCE;
Keywords:
mechanoreceptor; hair bundle; stereocilium; hair cell repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Watson, GM Univ SW Louisiana, Dept Biol, Box 42451, Lafayette, LA 70504 USA Univ SW Louisiana Box 42451 Lafayette LA USA 70504 LA 70504 USA
Citazione:
J.J. Repass e G.M. Watson, "Anemone repair proteins as a potential therapeutic agent for vertebrate hair cells: facilitated recovery of the lateral line of blind cave fish", HEARING RES, 154(1-2), 2001, pp. 98-107

Abstract

Blind cave fish use the lateral line sensory system to detect nearby objects. The fish responds to sudden perturbations in the water column by initiating startle responses in which they swim more rapidly. Normal startle responses disappear after trauma caused by a single 15 s immersion in calcium free water, but return within 5 days if the traumatized fish are treated with 'repair proteins' isolated from sea anemones. Polyclonal antibodies raised to fraction beta, a specific chromatographic fraction of repair proteins,bind to hair cells within superficial neuromasts. Likewise, biotinylated fraction beta binds to hair cells in neuromasts. Neuromast hair cells exposed to calcium free water followed by repair proteins have more compact hair bundles than do hair cells exposed only to calcium free water. We propose that anemone repair proteins replace linkages between stereocilia destroyed by exposure to calcium free water. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:49:55