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Titolo:
Plasticity in the adult human central auditory system: evidence from late-onset profound unilateral deafness
Autore:
Ponton, CW; Vasama, JP; Tremblay, K; Khosla, D; Kwong, B; Don, M;
Indirizzi:
House Ear Res Inst, Electrophysiol Lab, Los Angeles, CA 90057 USA House Ear Res Inst Los Angeles CA USA 90057 ab, Los Angeles, CA 90057 USA Univ Helsinki, Cent Hosp, Dept Otolaryngol, Helsinki 00290, Finland Univ Helsinki Helsinki Finland 00290 tolaryngol, Helsinki 00290, Finland Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 & Hearing Sci, Seattle, WA 98105 USA HRI Labs LLC, Malibu, CA 90265 USA HRI Labs LLC Malibu CA USA 90265HRI Labs LLC, Malibu, CA 90265 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 154, anno: 2001,
pagine: 32 - 44
SICI:
0378-5955(200104)154:1-2<32:PITAHC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORINEURAL HEARING-LOSS; INFERIOR COLLICULUS; CORTICAL RESPONSES; EVOKED-POTENTIALS; COCHLEAR NUCLEUS; MAGNETIC-FIELDS; CORTEX; LESIONS; SOUND; ORGANIZATION;
Keywords:
plasticity; auditory evoked potential; unilateral; deafness; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ponton, CW Neurosoft Inc, 5700 Cromo Dr,Suite 100, El Paso, TX 79912 USA Neurosoft Inc 5700 Cromo Dr,Suite 100 El Paso TX USA 79912 USA
Citazione:
C.W. Ponton et al., "Plasticity in the adult human central auditory system: evidence from late-onset profound unilateral deafness", HEARING RES, 154(1-2), 2001, pp. 32-44

Abstract

Experience-related changes in central nervous system (CNS) activity have been observed in the adult brain of many mammalian species, including humans. In humans, late-onset profound unilateral deafness creates an opportunityto study plasticity in the adult CNS consequent to monaural auditory deprivation. CNS activity was assessed by measuring long-latency auditory evokedpotentials (AEPs) recorded from teens and adults with late-onset (post-childhood) profound unilateral deafness. Compared to monaurally stimulated normal-hearing subjects, the AEPs recorded from central electrode sites located over auditory cortical areas showed significant increases in inter-hemispheric waveform cross-correlation coefficients. and in inter-hemispheric AEPpeak amplitude correlations. These increases provide evidence of substantial changes from the normal pattern of asymmetrical (contralateral > ipsilateral amplitude) and asynchronous (contralateral earlier than ipsilateral) central auditory system activation in the normal-hearing population to a much more symmetrical and synchronous activation in the unilaterally deaf These cross-sectional analyses of AEP data recorded from the unilaterally deaf also suggest that the changes in cortical activity occur gradually and continue for at least 2 years after the onset of hearing loss. Analyses of peakamplitude correlations suggest that the increased inter-hemispheric symmetry may be a consequence of changes in the generators producing the N-1 (approximately 100 ms peak latency) potential. These experience-related changesin central auditory system activity following late-onset profound unilateral deafness thus provide evidence of the presence and the time course of auditory system plasticity in the adult brain. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 14:46:39