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Titolo:
Lineage-specific gene expansions in bacterial and archaeal genomes
Autore:
Jordan, IK; Makarova, KS; Spouge, JL; Wolf, YI; Koonin, EV;
Indirizzi:
NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA NIH Bethesda MD USA 20894 Informat, Natl Lib Med, Bethesda, MD 20894 USA Uniformed Serv Univ Hlth Sci, Bethesda, MD 20894 USA Uniformed Serv Univ Hlth Sci Bethesda MD USA 20894 Bethesda, MD 20894 USA Russian Acad Sci, Inst Cytol & Genet, Novosibirsk 630090, Russia Russian Acad Sci Novosibirsk Russia 630090 t, Novosibirsk 630090, Russia
Titolo Testata:
GENOME RESEARCH
fascicolo: 4, volume: 11, anno: 2001,
pagine: 555 - 565
SICI:
1088-9051(200104)11:4<555:LGEIBA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS; DEINOCOCCUS RADIODURANS; HELICOBACTER-PYLORI; PROTEIN FAMILIES; SEQUENCE; EVOLUTION; DATABASE; NUMBER; ENTRY; CELLS;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Koonin, EV NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA NIH Bethesda MD USA 20894 Natl Lib Med, Bethesda, MD 20894 USA
Citazione:
I.K. Jordan et al., "Lineage-specific gene expansions in bacterial and archaeal genomes", GENOME RES, 11(4), 2001, pp. 555-565

Abstract

Gene duplication is an important mechanistic antecedent to the evolution of new genes and novel biochemical functions. In an attempt to assess the contribution of gene duplication to genome evolution in archaea and bacteria,clusters of related genes that appear to have expanded subsequent to the diversification of the major prokaryotic lineages (lineage-specific expansions) were analyzed. Analysis of 21 completely sequenced prokaryotic genomes shows that lineage-specific expansions comprise a substantial fraction (similar to5%-33%) of their coding capacities. A positive correlation exists between the fraction of the genes taken up by lineage-specific expansions andthe total number of genes in a genome. Consistent with the notion that lineage-specific expansions are made up of relatively recently duplicated genes, >90% of the detected clusters consists of only two to four genes. The more common smaller clusters tend to include genes with higher pairwise similarity (as reflected by average score density) than larger clusters. Regardless of size, cluster members tend to be located more closely on bacterial chromosomes than expected by chance, which could reflect a history of tandemgene duplication. In addition to the small clusters, almost all genomes also contain rare large clusters of size greater than or equal to 20. Severalexamples of the potential adaptive significance of these large clusters are explored. The presence or absence of clusters and their related genes wasused as the basis for the construction of a similarity graph for completely sequenced prokaryotic genomes. The topology of the resulting graph seems to reflect a combined effect of common ancestry, horizontal transfer,and lineage-specific gene loss.

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Documento generato il 22/09/20 alle ore 12:36:11