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Titolo:
Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis
Autore:
Ulm, R; Revenkova, E; di Sansebastiano, GP; Bechtold, N; Paszkowski, J;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland INRA, Genet & Ameliorat Plantes Stn, F-78026 Versailles, France INRA Versailles France F-78026 t Plantes Stn, F-78026 Versailles, France
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 6, volume: 15, anno: 2001,
pagine: 699 - 709
SICI:
0890-9369(20010315)15:6<699:MPKPIR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAP KINASE; UV-B; DNA-DAMAGE; HOMOLOGOUS RECOMBINATION; REGULATED EXPRESSION; TYROSINE PHOSPHATASE; SIGNAL-TRANSDUCTION; NEGATIVE REGULATOR; CHALCONE SYNTHASE; ULTRAVIOLET-LIGHT;
Keywords:
Arabidopsis; genotoxic stress; MAP kinase phosphatase; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Ulm, R Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 el, Switzerland
Citazione:
R. Ulm et al., "Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis", GENE DEV, 15(6), 2001, pp. 699-709

Abstract

Genotoxic stress activates complex cellular responses allowing for the repair of DNA damage and proper cell recovery. Although plants are exposed constantly to increasing solar UV irradiation, the signaling cascades activated by genotoxic environments are largely unknown. We have identified an Arabidopsis mutant (mkp1) hypersensitive to genotoxic stress treatments (UV-C and methyl methanesulphonate) due to disruption of a gene that encodes an Arabidopsis homolog of mitogen-activated protein kinase phosphatase (AtMKP1). Growth of the mkp1 mutant under standard conditions is indistinguishable from wild type, indicating a stress-specific function of AtMKP1. MAP kinase phosphatases (MKPs), the potent inactivators of MAP kinases, are consideredimportant regulators of MAP kinase signaling. Although biochemical data from mammalian cell cultures suggests an involvement of MKPs in cellular stress responses, there is no in vivo genetic support for this view in any multicellular organism. The genetic and biochemical data presented here imply acentral role for a MAP kinase cascade in genotoxic stress signaling in plants and indicate AtMKP1 to be a crucial regulator of the MAP kinase activity in vivo, determining the outcome of the cellular reaction and the level of genotoxic resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:02:08