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Titolo:
Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upperGI bleeding? A prospective study of 977 patients
Autore:
Chan, HLY; Wu, JCY; Chan, FKL; Choi, CL; Ching, JYL; Lee, YT; Leung, WK; Lau, JYW; Chung, SCS; Sung, JJY;
Indirizzi:
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China Chinese Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong,Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong Peoples R China oples R China
Titolo Testata:
GASTROINTESTINAL ENDOSCOPY
fascicolo: 4, volume: 53, anno: 2001,
pagine: 438 - 442
SICI:
0016-5107(200104)53:4<438:INPNPU>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RISK-FACTORS; UNITED-STATES; DUODENAL-ULCER; INFECTION; DISEASE; THERAPY; BLOOD; METAANALYSIS; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sung, JJY Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China Prince Wales Hosp Shatin Hong Kong Peoples R China les R China
Citazione:
H.L.Y. Chan et al., "Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upperGI bleeding? A prospective study of 977 patients", GASTROIN EN, 53(4), 2001, pp. 438-442

Abstract

Background: Non-Helicobacter pylori, non-NSAID ulcer is relatively common in Western countries. Whether it is a significant problem in the Orient is unclear. The aim of this study was to investigate the incidence of non-H pylori, non-NSAID ulcers presenting with GI bleeding. Methods: A prospective study was done of 1675 consecutive patients presenting with upper GI bleeding over a period of 12 months. Upper endoscopy was performed with biopsy specimens taken from the antrum and body of the stomach for a biopsy urease test (BUT) and histology for detection of H pylori, Exposure to nonsteroidal anti-inflammatory drugs (NSAID) or aspirin within 4 weeks of hospitalization was carefully scrutinized. A B-week course of treatment with an H-2-receptor antagonist was prescribed for patients who didnot use an NSAID and had a negative BUT result. Follow-up endoscopy was performed to confirm H pylori status with a BUT and histology, Positive histology at either initial or follow-up endoscopy was used as the standard for diagnosing H pylori infection. Results: Among 977 patients who were found to have ulcer bleeding, 434 (44%) had exposure to aspirin or an NSAID, Of the 543 non-NSAID users, 431 (79.4%) had a positive BUT and 112 (20.6%) were BUT negative on initial endoscopy. Eighty-nine of 112 patients who were NSAID negative, BUT negative returned for follow-up endoscopy. Forty-nine of 89 (55.1%) were found to have apositive BUT and positive histology at follow-up endoscopy, Only 40 of 977(4.1%) patients admitted with ulcer bleeding were confirmed to have non-H pylori, non-NSAID ulcers. Conclusions: Non-H pylori, non-NSAID bleeding ulcer is uncommon. A negative BUT is unreliable for exclusion of H pylori infection during the acute phase of ulcer bleeding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:50:31