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Titolo:
Neurobiological bases underlying the control of the onset of puberty in the rhesus monkey: A representative higher primate
Autore:
Plant, TM;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Physiol, Pittsburgh, PA 15261 USA
Titolo Testata:
FRONTIERS IN NEUROENDOCRINOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 107 - 139
SICI:
0091-3022(200104)22:2<107:NBUTCO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; FOLLICLE-STIMULATING-HORMONE; GLUTAMIC-ACID DECARBOXYLASE; GROWTH-FACTOR-ALPHA; NEUROPEPTIDE-Y NPY; GAMMA-AMINOBUTYRIC-ACID; CENTRAL-NERVOUS-SYSTEM; STALK-MEDIAN EMINENCE; LUTEINIZING-HORMONE; MACACA-MULATTA;
Keywords:
puberty; GnRH release; GnRH gene expression; NPY; GABA; rhesus monkey; glutamate; postnatal development; sex differences;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Plant, TM Univ Pittsburgh, Sch Med, Dept Cell Biol & Physiol, S-828A Scaife Hall, Pittsburgh, PA 15261 USA Univ Pittsburgh S-828A Scaife Hall Pittsburgh PA USA 15261 1 USA
Citazione:
T.M. Plant, "Neurobiological bases underlying the control of the onset of puberty in the rhesus monkey: A representative higher primate", FRONT NEURO, 22(2), 2001, pp. 107-139

Abstract

The purpose of this article is to discuss our understanding of the neurobiological mechanisms that govern the timing of the onset of puberty in the rhesus monkey, a representative higher primate, and, whenever possible, to place findings obtained from studies of this macaque in perspective with those for the human situation. Specifically, the dynamics in the postnatal ontogeny of hypothalamic GnRH gene expression and release are described, and the roles of neuropeptide Y and gamma -aminobutyric acid in imposing the restraint on pulsatile GnRH release during juvenile development are examined. Finally, the hypothesis that circulating leptin provides the signal that times the reaugmentation of pulsatile GnRH release at the termination of juvenile development, and therefore triggers the onset of primate puberty, is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:06:26