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Titolo:
Progesterone receptors as neuroendocrine integrators
Autore:
Levine, JE; Chappell, PE; Schneider, JS; Sleiter, NC; Szabo, M;
Indirizzi:
Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 & Physiol, Evanston, IL 60208 USA
Titolo Testata:
FRONTIERS IN NEUROENDOCRINOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 69 - 106
SICI:
0091-3022(200104)22:2<69:PRANI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; FOLLICLE-STIMULATING-HORMONE; RAT ESTROUS-CYCLE; LIGAND-INDEPENDENT ACTIVATION; EPIDERMAL GROWTH-FACTOR; GUINEA-PIG BRAIN; ANTERIOR-PITUITARY GLAND; CASTRATE FEMALE RATS; PUSH-PULL CANNULAE; LUTEINIZING-HORMONE;
Keywords:
progesterone; progesterone receptor; estrogen; estrogen receptor; hypothalamus; pituitary gland; GnRH; LH; FSH; anteroventral periventricular nucleus; cAMP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
188
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, JE Northwestern Univ, Dept Neurobiol & Physiol, 2153 N Campus Dr, Evanston, IL 60208 USA Northwestern Univ 2153 N Campus Dr Evanston IL USA 60208 08 USA
Citazione:
J.E. Levine et al., "Progesterone receptors as neuroendocrine integrators", FRONT NEURO, 22(2), 2001, pp. 69-106

Abstract

Intracellular progesterone receptors (PRs) are ligand-inducible transcription factors that mediate the majority of the effects of progesterone (P) onneuroendocrine functions. During the past decade, evidence has accumulatedwhich suggest that PRs can also be activated independently of P, by signals propagated through membrane-bound receptors to the interior of cells. Theactivation of PRs by this type of "cross-talk" mechanism has been implicated in the physiological regulation of several important neuroendocrine processes, including estrous behavior and periovulatory hormone secretions. We review evidence that both ligand-dependent and ligand-independent activation of PRs occurs in central neurons and in anterior pituitary cells and thatthe convergence and summation of these signals at the PR serves to integrate neural and endocrine signals which direct several critically important neuroendocrine processes. An integrative function for PRs is reviewed in several physiological contexts, including the display of lordosis behavior in female rodents, the neurosecretion of gonadotropin-releasing hormone surges, secretion of preovulatory gonadotropin surges, and release of periovulatory follicle stimulating hormone surges. The weight of evidence indicates that cross talk at the intracellular PR is an essential component of the integrative mechanisms that direct each of these neuroendocrine events. The recurrence of PR's integrative actions in several different physiological contexts suggests that other intracellular steroid receptors similarly functionas integrators of neural and endocrine signals in other neuroendocrine processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:05:08