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Titolo:
Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones
Autore:
Sutton, JM; Chow-Worn, O; Spaven, L; Silman, NJ; Hallis, B; Shone, CC;
Indirizzi:
Publ Hlth Lab Serv, Ctr Appl Microbiol & Res, Salisbury SP4 0JG, Wilts, England Publ Hlth Lab Serv Salisbury Wilts England SP4 0JG P4 0JG, Wilts, England
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 493, anno: 2001,
pagine: 45 - 49
SICI:
0014-5793(20010323)493:1<45:TOTNPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN MEMBRANES; TOXIN FRAGMENT-C; H-C; HEAVY SUBUNIT; A NEUROTOXIN; RECEPTOR; DOMAIN;
Keywords:
tetanus; botulinum; ganglioside; neurotoxin; receptor; motoneuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Shone, CC Publ Hlth Lab Serv, Ctr Appl Microbiol & Res, Porton Down, Salisbury SP4 0JG, Wilts, England Publ Hlth Lab Serv Porton Down Salisbury WiltsEngland SP4 0JG d
Citazione:
J.M. Sutton et al., "Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones", FEBS LETTER, 493(1), 2001, pp. 45-49

Abstract

Tetanus toxin acts by blocking the release of glycine from inhibitory neurones within the spinal cord, An initial stage in the toxin's action is binding to acceptors on the nerve surface and polysialogangliosides are a component of these acceptor moieties, Using site-directed mutagenesis, we identify tyrosine-1290 of tetanus toxin as a key residue that is involved in ganglioside binding, This residue, which is located at the centre of a shallow pocket on the beta -trefoil domain of the tetanus H-c fragment, is also shown to play a key role in the functional binding of tetanus toxin to spinal cord neurones leading to the inhibition of neurotransmitter release. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:00:03