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Titolo:
Ischemia-induced degeneration of CA1 pyramidal cells decreases seizure severity in a subgroup of epileptic gerbils and affects parvalbumin immunoreactivity of CA1 interneurons
Autore:
Winkler, DT; Scotti, AL; Nitsch, C;
Indirizzi:
Univ Basel, Inst Anat, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 st Anat, CH-4056 Basel, Switzerland Univ Bern, Inst Pharmacol, CH-3012 Bern, Switzerland Univ Bern Bern Switzerland CH-3012 Pharmacol, CH-3012 Bern, Switzerland
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 168, anno: 2001,
pagine: 364 - 372
SICI:
0014-4886(200104)168:2<364:IDOCPC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; BINDING PROTEIN PARVALBUMIN; DELAYED NEURONAL DEATH; RAT DENTATE GYRUS; SENSITIVE GERBIL; GABAERGIC INTERNEURONS; SYNAPTIC TRANSMISSION; HIPPOCAMPAL-NEURONS; PERFORANT PATH; IN-VIVO;
Keywords:
Meriones unguiculatus; stroke; epilepsy; kindling; temporal lobe; hippocampus; calcium-binding proteins; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Nitsch, C Univ Basel, Inst Anat, Pestalozzistr 20, CH-4056 Basel, Switzerland Univ Basel Pestalozzistr 20 Basel Switzerland CH-4056 itzerland
Citazione:
D.T. Winkler et al., "Ischemia-induced degeneration of CA1 pyramidal cells decreases seizure severity in a subgroup of epileptic gerbils and affects parvalbumin immunoreactivity of CA1 interneurons", EXP NEUROL, 168(2), 2001, pp. 364-372

Abstract

Mongolian gerbils are epilepsy-prone animals, In adult gerbils two major groups can be differentiated according to their seizure behavior: Highly seizure-sensitive gerbils exhibit facial and forelimb clonus or generalized tonic-clonic seizures from the first test on, while kindled-like gerbils are seizure free for the first three to six consecutive tests, later develop forelimb myoclonus, and eventually progress to generalized tonic-clonic seizures. In the hippocampus, seizure history of the individual animal is mirrored in the intensity in which GABAergic neurons are immunostained for the calcium-binding protein parvalbumin: they lose parvalbumin with increasing seizure incidence. In a first step to clarify the influence of hippocampal projection neurons on spontaneous seizure behavior and related parvalbumin expression, we induced degeneration of the CA1 pyramidal cells by transient forebrain ischemia, This results in a decreased seizure sensitivity in highly seizure-sensitive gerbils, The kindling-like process, however, is not permanently blocked by the ischemic nerve cell loss, suggesting that an intactCA1 field is not a prerequisite for the development of seizure behavior. The seizure-induced loss of parvalbumin from the ischemia-resistant interneurons recovers after ischemia, Thus, changes in parvalbumin content brought about by repeated seizures are not permanent but can rather be modulated bynovel stimuli. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:33:57