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Titolo:
Involvement of L-DNase II in nuclear degeneration during chick retina development
Autore:
Torriglia, A; Chaudun, E; Chany-Fournier, F; Courtois, Y; Counis, MF;
Indirizzi:
Assoc Claude Bernard, Affiliee CNRS, INSERM, Unite 450, F-75016 Paris, France Assoc Claude Bernard Paris France F-75016 ite 450, F-75016 Paris, France
Titolo Testata:
EXPERIMENTAL EYE RESEARCH
fascicolo: 4, volume: 72, anno: 2001,
pagine: 443 - 453
SICI:
0014-4835(200104)72:4<443:IOLIIN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; HUMAN DEOXYRIBONUCLEASE-II; APOPTOTIC RAT THYMOCYTES; CASPASE-ACTIVATED DNASE; MOLECULAR-CLONING; INTERNUCLEOSOMAL FRAGMENTATION; ENDONUCLEASE ACTIVATION; DEPENDENT ENDONUCLEASE; CLEAVAGE; INHIBITOR;
Keywords:
DNases; retina development; apoptosis; L-DNase II; DNase I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Torriglia, A Assoc Claude Bernard, Affiliee CNRS, INSERM, Unite 450, 29 Rue Wilhem, F-75016 Paris, France Assoc Claude Bernard 29 Rue Wilhem Paris France F-75016 ance
Citazione:
A. Torriglia et al., "Involvement of L-DNase II in nuclear degeneration during chick retina development", EXP EYE RES, 72(4), 2001, pp. 443-453

Abstract

During the development of the neural retina, 50 % of the neurons die physiologically by apoptosis. Tn the chick embryo, the apoptotic wave starts at E8 and ends at E18, with a peak at E11. The onset of apoptosis is accompanied by the activation of several degradative enzymes. Among these, the activation of the endonucleases leads to the degradation of tho genomic DNA of the cell which is thought to he the final event in apoptosis. Here, we have investigated the endonucleases activated during apoptosis associated with retinal development. We have found that Ca2+-Mg2+-dependant endonucleases, as well as acid endonucleases are activated. The results obtained in vitro using purified nuclei from chicken retina indicate that the endonuclease activity resulting From the activation of L-DNase II, an acid DNase is responsible for most of the DNA degradation observed in these cells. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 05:30:49