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Titolo:
EGF regulates a complex pattern of gene expression and represses smooth muscle differentiation during the neurotypic conversion of the neural-crest-derived TC-1S cell line
Autore:
Giannini, G; Alesse, E; Di Marcotullio, L; Zazzeroni, F; Gallo, R; Zani, M; Frati, L; Screpanti, I; Gulino, A;
Indirizzi:
Univ Rome La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 d & Pathol, I-00161 Rome, Italy Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 Dept Expt Med, I-67100 Laquila, Italy Neuromed Inst, Pazzilli, Italy Neuromed Inst Pazzilli ItalyNeuromed Inst, Pazzilli, Italy Inst Pasteur, Cenci Bolognetti Fdn, I-00161 Rome, Italy Inst Pasteur Rome Italy I-00161 enci Bolognetti Fdn, I-00161 Rome, Italy
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 2, volume: 264, anno: 2001,
pagine: 353 - 362
SICI:
0014-4827(20010401)264:2<353:ERACPO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC EPITHELIAL-CELLS; GROWTH-FACTOR; MYASTHENIA-GRAVIS; PROGENITOR CELLS; BINDING-PROTEIN; MYOID CELLS; STEM-CELLS; TGF-BETA; IN-VIVO; NF-Y;
Keywords:
EGF-responsive genes; EGF; TGF beta; neural crest; differential display; smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Gulino, A Univ Rome La Sapienza, Dept Expt Med & Pathol, 324 Viale Regina Elena, I-00161 Rome, Italy Univ Rome La Sapienza 324 Viale Regina Elena Rome Italy I-00161
Citazione:
G. Giannini et al., "EGF regulates a complex pattern of gene expression and represses smooth muscle differentiation during the neurotypic conversion of the neural-crest-derived TC-1S cell line", EXP CELL RE, 264(2), 2001, pp. 353-362

Abstract

EGF, known to sustain CNS neuronal progenitors, also promotes a neurotypicresponse in the thymic neural-crest-derived TC-1S cell line. We report here the use of TC-1S cells as a model to identify the genetic programs regulated during the neurotypic response induced by EGF and to isolate 23 EGF-responsive genes. Among them 5 represent novel cDNAs, while 18 are known genes, whose regulation by EGF is associated with the mitogenic or differentiating effects of the growth factor. The repression of smooth muscle alpha -actin and SM22 alpha genes by EGF and their increase by TGF beta suggest that the TC-1S line includes neural crest multipotent cells whose smooth muscle differentiation is repressed upon EGF treatment and stimulated by TGF beta. Therefore, we identified a complex pattern of EGF-target genes and proposeEGF as a novel signal able to recruit postmigratory neural-crest-derived cells along proliferation and cell lineage choice pathways. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:34:26