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Titolo:
A brief neuropsychological assessment for the differential diagnosis between frontotemporal dementia and Alzheimer's disease
Autore:
Siri, A; Benaglio, I; Frigerio, A; Binetti, G; Cappa, SF;
Indirizzi:
IRCCS Giovanni di Dio, Neuropsychol Lab, Brescia, Italy IRCCS Giovanni di Dio Brescia Italy o, Neuropsychol Lab, Brescia, Italy Univ Milan, I-20122 Milan, Italy Univ Milan Milan Italy I-20122Univ Milan, I-20122 Milan, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 125 - 132
SICI:
1351-5101(200103)8:2<125:ABNAFT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE TYPE; DYSFUNCTION; TESTS; DEGENERATION; FEATURES;
Keywords:
Alzheimer's disease; frontotemporal dementia; neuropsychological assessment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Cappa, SF IRCCS Giovanni di Dio, Neuropsychol Lab, Via Pilastroni 4, Brescia, Italy IRCCS Giovanni di Dio Via Pilastroni 4 Brescia Italy ia, Italy
Citazione:
A. Siri et al., "A brief neuropsychological assessment for the differential diagnosis between frontotemporal dementia and Alzheimer's disease", EUR J NEUR, 8(2), 2001, pp. 125-132

Abstract

The neuropsychological performance (including measures of language, semantic memory, visual and spatial perception and executive functions) of a group of 14 patients with the clinical diagnosis of probable frontotemporal dementia was compared with that of a group of 14 patients with a clinical diagnosis of probable Alzheimer's disease. The aim was to identify a specific cognitive profile of frontotemporal dementia, which could be used to select a sensitive, short evaluation for the differential diagnosis with Alzheimer's disease. Both groups were severely impaired in most tasks, including those 'frontal lobe' tests which have been suggested to play an important rolein differential diagnosis. Significant differences were found only for a minority of tests (oral praxis, visual-spatial perception, and verbal fluency). A logistic regression showed that a shortened testing procedure based on four tests (Rey-Osterreith complex figure test recall, phonemic fluency, oral apraxia, and cube analysis) achieved a 70% sensitivity and 80% specificity for the correct classification of patients in the frontotemporal dementia or Alzheimer's disease group. In conclusion, a brief neuropsychologicalevaluation including these four tests, as well as other measures sensitiveto the frontal impairment, can be useful in the differential diagnosis between the two pathologies, along with the clinical data.

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Documento generato il 22/01/20 alle ore 06:22:28