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Titolo:
Skeletal responsiveness to parathyroid hormone in pseudohypoparathyroidism
Autore:
Kanatani, M; Sugimoto, T; Kaji, H; Ikeda, K; Chihara, K;
Indirizzi:
Kobe Univ, Sch Med, Dept Med, Div 3,Chuo Ku, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 Med, Div 3,Chuo Ku, Kobe, Hyogo 650, Japan
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 144, anno: 2001,
pagine: 263 - 269
SICI:
0804-4643(200103)144:3<263:SRTPHI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE RECEPTOR GENE; METAPHYSEAL CHONDRODYSPLASIA; DEOXYRIBONUCLEIC-ACID; SKIN FIBROBLASTS; DNA METHYLATION; IB; RESISTANCE; EXPRESSION; MUTATIONS; SPECTRUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Sugimoto, T Kobe Univ, Sch Med, Dept Med, Div 3,Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 650, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 650o 650, Japan
Citazione:
M. Kanatani et al., "Skeletal responsiveness to parathyroid hormone in pseudohypoparathyroidism", EUR J ENDOC, 144(3), 2001, pp. 263-269

Abstract

Background: Although there have been some case reports suggesting that bone in patients with pseudohypoparathyroidism (PHP) might respond to parathyroid hormone (PTH), no information is available as to whether serum PTH concentration is related to bone metabolic markers or to bone mineral density (BMD) in PHP,Objective: To address these relationships, by comparing intact serum PTH, bone metabolic markers and BMD in patients with PHP with those in patients with idiopathic hypoparathyroidism (IHP) and postoperative hypoparathyroidism (OHP),Methods: Intact serum PTH, bone metabolic markers (osteocalcin, tartrate-resistant acid phosphatase, pyridinoline, deoxypyridinoline) and BMD by dual-energy X-ray absorptiometry or single-photon absorptiometry were measured in patients with PHP Ia (n = 2) and PHP Ib (n = 8). The results were compared with those in patients with IHP (n = 5) and OHP (n = 14). Results: All bone metabolic markers measured were present in significantlygreater amounts in patients with PHP Ib than in those with IHP+OHP. The Z score (standard deviation of average BMD at each age) of the BMD of femoralneck was significantly lower in patients with PHP Ib than in those with IHP+OHP, The Z scores of BMD of lumbar spine and radius were also lower in patients with PHP Ib than in those with IHP+OHP, but the difference was not significant. Moreover, the intact serum PTH concentrations were significantly and positively related to bone metabolic marker levels in all patients, and the intact serum PTH concentrations were significantly and negatively related to BMD of lumbar spine in PHP patients. Conclusions: These results suggest that PTH stimulates bone turnover in PHP Ib patients, resulting in a relatively lower BMD in PHP Ib patients than in IHP+OHP patients. The present study indicates that bones of most cases of PHP could respond to PTH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:58:22