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Titolo:
Analysis of the direct cost of adverse drug reactions in hospitalised patients
Autore:
Bordet, R; Gautier, S; Le Louet, H; Dupuis, B; Caron, J;
Indirizzi:
Hop Claude Huriez, Serv Pharmacol Hosp, F-59045 Lille, France Hop Claude Huriez Lille France F-59045 macol Hosp, F-59045 Lille, France CHet U Lille, Ctr Reg Pharmacovigilance, Lille, France CHet U Lille Lille France lle, Ctr Reg Pharmacovigilance, Lille, France Agence Medicament, Paris, France Agence Medicament Paris FranceAgence Medicament, Paris, France CHet U Lille, Unite Evaluat, Lille, France CHet U Lille Lille FranceCHet U Lille, Unite Evaluat, Lille, France
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 12, volume: 56, anno: 2001,
pagine: 935 - 941
SICI:
0031-6970(200103)56:12<935:AOTDCO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENTS; SURVEILLANCE; ADMISSIONS; MORTALITY; ILLNESS;
Keywords:
adverse drug reactions; hospitalisation; cost;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Caron, J Hop Claude Huriez, Serv Pharmacol Hosp, 1 Pl Verdun, F-59045 Lille, France Hop Claude Huriez 1 Pl Verdun Lille France F-59045 Lille, France
Citazione:
R. Bordet et al., "Analysis of the direct cost of adverse drug reactions in hospitalised patients", EUR J CL PH, 56(12), 2001, pp. 935-941

Abstract

The hospitalised patients in a cardiological hospital (Lille, France) overan 18-month period were subjected to a prospective high-intensity adverse drug reaction (ADR) monitoring in order to assess the additional financial resource utilisation associated with ADRs and analyse the distribution of excess of cost according to ADR nature and therapeutic classes. Over 18 months, among the 16,916 hospitalised patients, 371 verified ADRs detected by self-report stimulated by a special unit of nurses and pharmacologists occurred in 336 patients with an overall ADR rate of 2.2%. This rate increased with age. The most common reactions were cutaneous events (24%), cardiovascular events (21%), metabolic disorders (12%), coagulation disorders (10%) and nervous system impairment (10%). The most common drug classes involved were cardiovascular agents (36%), contrast media (20%), drugs affecting bloodclotting (13%) and anti-infectives (14%). Increased ADR-induced costs result especially from prolongation of length of stay and cost increase was evaluated at Euro 4150 per ADR. Among the 371 ADRs, 134 ADRs, which were significantly more severe, induced a prolongation of length of stay. RenaI insufficiency and cardiovascular events were significantly over-represented in this sub-group. The most common ADR-inducing drugs associated with a prolongation of length of stay are cardiovascular agents and drugs affecting bloodclotting. In contrast, cutaneous ADRs were significantly over-represented in the group of ADRs without prolongation of length of stay. The severity and substantial costs of ADRs in hospital justify investments to prevent these events. Nevertheless, only a portion of ADRs induces cost increases, suggesting that prevention efforts should focus on this limited category of ADRs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:26:32