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Titolo:
The effect of vagus nerve stimulation on epileptiform activity recorded from hippocampal depth electrodes
Autore:
Olejniczak, PW; Fisch, BJ; Carey, M; Butterbaugh, G; Happel, L; Tardo, C;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Neurol, Sch Med,Comprehens Epilepsy Ctr, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112, New Orleans, LA 70112 USA
Titolo Testata:
EPILEPSIA
fascicolo: 3, volume: 42, anno: 2001,
pagine: 423 - 429
SICI:
0013-9580(200103)42:3<423:TEOVNS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL EPILEPSY; SEIZURES; HUMANS;
Keywords:
vague nerve stimulation; hippocampal depth electrodes; epileptiform activity; spikes; sharp waves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fisch, BJ Louisiana State Univ, Med Ctr, Dept Neurol, Sch Med,Comprehens Epilepsy Ctr, 1542 Tulane Ave, New Orleans, LA 70112 USA Louisiana State Univ 1542 Tulane Ave New Orleans LA USA 70112 SA
Citazione:
P.W. Olejniczak et al., "The effect of vagus nerve stimulation on epileptiform activity recorded from hippocampal depth electrodes", EPILEPSIA, 42(3), 2001, pp. 423-429

Abstract

Purpose: To assess the effect of vagus nerve stimulation (VNS) on interictal epileptiform activity in the human hippocampus. Clinical studies have established the efficacy of vagus nerve stimulation in patients with epilepsy(VNS Study Group, 1995), although the electrophysiologic effects of VNS onthe human hippocampus and mesial temporal lobe structures remain unknown. Methods: We report a case study in which a patient with an implanted VNS underwent intracranial electrode recording before temporal lobectomy for intractable complex partial seizures. Epileptiform spikes and sharp waves wererecorded from a depth electrode placed in the patient's left hippocampus. Spike frequencies and sharp-wave frequencies before and during VNS were compared using both a 5- and a 30-Hz stimulus. Different stimulation rates were tested on different days, and all analyses were performed using a Student's t test. Results: We found no significant differences in spike frequency between baseline periods and stimulation at 5 and 30 Hz. In contrast. stimulation at 30 Hz produced a significant decrease in the occurrence of epileptiform sharp waves compared with the baseline, whereas stimulation at 5 Hz was associated with a significant increase in the occurrence of epileptiform sharp waves. Conclusions: VNS produces a measurable electrophysiologic effect on epileptiform activity in the human hippocampus. Although a clinical response to VNS did not occur in our patient before surgery, 30-Hz VNS suppressed interictal epileptiform sharp waves that were similar in appearance to those seenduring the patient's actual seizures. In contrast, 5-Hz stimulation appeared to increase the appearance of interictal sharp waves.

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Documento generato il 09/07/20 alle ore 18:49:12