Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hexarelin, but not growth hormone, protects heart from damage induced in vitro by calcium deprivation replenishment
Autore:
Torsello, A; Rossoni, G; Locatelli, V; Colonna, VD; Bernareggi, M; Francolini, M; Muller, EE; Berti, F;
Indirizzi:
Univ Milan, Dept Expt & Environm Med & Biotechnol, Milan, Italy Univ Milan Milan Italy t Expt & Environm Med & Biotechnol, Milan, Italy Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, Milan, Italy Univ Milan Milan Italy armacol Chemotherapy & Med Toxicol, Milan, Italy Univ Milan, Inst Pharmacol Sci, Milan, Italy Univ Milan Milan ItalyUniv Milan, Inst Pharmacol Sci, Milan, Italy
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 109 - 112
SICI:
1355-008X(200102)14:1<109:HBNGHP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARADOX; RATS; ISCHEMIA; PEPTIDE; TISSUE;
Keywords:
hexarelin; growth hormone secretagogue; heart; calcium paradox; growth hormone-releasing peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Torsello, A Univ Milan, Dept Pharmacol, Via Vanvitelli 32, I-20129 Milan, Italy Univ Milan Via Vanvitelli 32 Milan Italy I-20129 Milan, Italy
Citazione:
A. Torsello et al., "Hexarelin, but not growth hormone, protects heart from damage induced in vitro by calcium deprivation replenishment", ENDOCRINE, 14(1), 2001, pp. 109-112

Abstract

The effects of hexarelin, a growth hormone (GH) secretagogue, and human GHon the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied. Hexarelin (80 mug/kg bid, subcutaneously) administered for 7 d to male rats effectively antagonized the sudden increase in resting tension measured in vitro on Ca2+ repletion. Moreover, during Ca2+ repletion the release of creatine kinase activity (an index of cell damage) in the perfusate of these hearts was reduced up to 40% compared with controls. By contrast, administration of hexarelin for 3 d or GH (400 mug/kg bid, subcutaneously) for 7 d did not affect the mechanical and metabolic alterations induced by the calcium paradox. To assess its direct and acute cardiac effects, hexarelin (8 mug/ml) was perfused in vitro in recirculating conditions for 60 min through the hearts of normal rats. In this case, hexarelin did not stimulate heart contractility and failed to prevent ventricular contracture upon Ca2+ readmission, whereas diltiazem, a Ca(2+)channel blocker, effectively antagonized thecalcium paradox phenomenon. We conclude that short-term in vivo exposure to hexarelin, but not GH, enables cardiac myocyites to prevent cytoplasmaticelectrolytic unbalance and to control intracellular Ca2+ gain, two functions largely impaired during the calcium paradox phenomenon. Moreover, because the effect of hexarelin is not acute but dependent on the length of in vivo treatment, we suggest that it requires modifications of myocardiocyte physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:50:07