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Titolo:
Growth hormone secretagogues as diagnostic tools in disease states
Autore:
Baldelli, R; Otero, XL; Camina, JP; Gualillo, O; Popovic, V; Dieguez, C; Casanueva, FF;
Indirizzi:
Univ Santiago de Compostela, Dept Med, Endocrine Unit, E-15780 Santiago DeCompostela, Spain Univ Santiago de Compostela Santiago De Compostela Spain E-15780 , Spain Univ Santiago de Compostela, Dept Physiol, E-15780 Santiago De Compostela,Spain Univ Santiago de Compostela Santiago De Compostela Spain E-15780 a,Spain Univ Belgrade, Ctr Clin, Inst Endocrinol, YU-11000 Belgrade, Yugoslavia Univ Belgrade Belgrade Yugoslavia YU-11000 YU-11000 Belgrade, Yugoslavia
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 95 - 99
SICI:
1355-008X(200102)14:1<95:GHSADT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; INSULIN TOLERANCE-TEST; SYNTHETIC HEXAPEPTIDE; OBESE SUBJECTS; PLUS GHRP-6; SECRETION; PEPTIDE; PITUITARY; ADULTS; REPRODUCIBILITY;
Keywords:
growth hormone secretagogues as diagnostic; tools;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Casanueva, FF Univ Santiago de Compostela, Dept Med, Endocrine Unit, St SD-N POB 563, E-15780 Santiago De Compostela, Spain Univ Santiago de Compostela St SD-N POB 563 Santiago De Compostela Spain E-15780
Citazione:
R. Baldelli et al., "Growth hormone secretagogues as diagnostic tools in disease states", ENDOCRINE, 14(1), 2001, pp. 95-99

Abstract

One of the most active topics in the growth hormone-IGF-1 field is that ofthe so-called growth hormone secretagogues (CHS), At a time when the isolation of GHRH had not occurred, the GHS were developed as artificial tools to release GH, The interest in these groups of compounds was rekindled when it was realized that they were not surrogates of GHRH nor were they acting through the modulation of the release of either GHRH or somatostatin, With the subsequent cloning of the specific receptor of CHS, and today of the natural ligand for that receptor, named ghrelin, it soon become clear that GHS and the GHS-receptor were part of a new physiological system involved in GH regulation. The dual control of GH secretion became a trinity, GHS releases GH when administered by any route-oral, iv, sc, and even transdermally-with a surprising potency and reproductivity. In addition, GHS when administered together with GHRH exert a synergistic action on CH secretion and that combined administration is the most potent GH releaser to date. Clinical studies have demonstrated that the GHS-GHRH administration may be considered the new "gold standard" test of GH reserve in humans, as the GH secretionso elicited is not altered by gender, adiposity, or age. The combined administration of GHRH plus GHS is able to discriminate between healthy subjects and patients with adult CH deficiency, suggesting a considerable utility in the clinical setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:52:16