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Titolo:
Biologic activities of growth hormone secretagogues in humans
Autore:
Ghigo, E; Arvat, E; Giordano, R; Brogio, F; Gianotti, L; Maccario, M; Bisi, G; Graziani, A; Papotti, M; Muccioli, G; Deghenghi, R; Camanni, F;
Indirizzi:
Univ Turin, Dept Internal Med, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Internal Med, Turin, Italy Univ Turin, Dept Genet, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Genet, Turin, Italy Univ Turin, Dept Biochem, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Biochem, Turin, Italy Univ Turin, Dept Biomed Sci, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Biomed Sci, Turin, Italy Univ Turin, Dept Pharmacol, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Pharmacol, Turin, Italy Europeptides, Argenteuil, France Europeptides Argenteuil FranceEuropeptides, Argenteuil, France
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 87 - 93
SICI:
1355-008X(200102)14:1<87:BAOGHS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; SYNTHETIC HEXAPEPTIDE; NEUROTENSIN RECEPTORS; PEPTIDE HEXARELIN; CUSHINGS-SYNDROME; CARDIAC ISCHEMIA; ELDERLY SUBJECTS; DEFICIENT RATS; NEUROPEPTIDE-Y;
Keywords:
growth hormone secretagogues; prolactin; adrenocorticotropic hormone; cortisol; cardiovascular system; thyroid gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Ghigo, E Osped Molinette, Div Endocrinol, Corso Dogliotti 14, I-10126 Turin, Italy Osped Molinette Corso Dogliotti 14 Turin Italy I-10126 in, Italy
Citazione:
E. Ghigo et al., "Biologic activities of growth hormone secretagogues in humans", ENDOCRINE, 14(1), 2001, pp. 87-93

Abstract

Growth hormone secretagogues (GHSs) are synthetic peptidyl and nonpeptidylmolecules with strong, dose-dependent, and reproducible growth hormone (GH)releasing activity even after oral administration. GHSs release GH via actions on specific receptors (GHS-R) at the pituitary and, mainly, at the hypothalamic levels. GHSs likely act as functional somatostatin antagonists and meantime enhance the activity of CH-releasing hormone (GHRH)-secreting neurons. The CH-releasing effect of GHSs is independent of gender but undergoes marked age-related variations. Estrogens play a major role in enhancing the GH response to GHSs at puberty, which GHRH hypoactivity, somatostatinergic hyperactivity and impaired activity of the the putative GHS-like ligandand receptors probably explain the reduced GH-releasing effect of GHSs in aging. The activity of GHSs is not fully specific for CH. Their slight prolactin-releasing activity probably comes from direct pituitary action. In physiological conditions, the ACTH-releasing activity of GHSs is dependent oncentral actions; a direct action on GHS-R in pituitary ACTH-secreting tumors likely explains the peculiar ACTH and cortisol hyperresponsiveness to GHSs in Gushing disease. GHSs have specific receptor subtypes in other central and peripheral endocrine and nonendocrine tissues mediating CH-independent biologic activities. GHSs influence sleep pattern, stimulate food intake,and have cardiovascular activities. GHs have specific binding in normal and neoplastic follicular derived human thyroid tissue and inhibit the proliferation of follicular-derived neoplastic cell lines. The discovery of ghrelin, a 28 amino acid peptide synthesized in the stomach but also in other tissues, has opened new fascinating perspectives of research in this field.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:26:23