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Titolo:
Central actions of the nonpeptide growth hormone secretagogue GHS-25
Autore:
Bailey, ART; Gilliver, L; Leng, G; Smith, RG;
Indirizzi:
Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ton Ctr Aging, Houston, TX 77030 USA Univ Edinburgh, Dept Biomed Sci, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 15 - 19
SICI:
1355-008X(200102)14:1<15:CAOTNG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ARCUATE NUCLEUS; C-FOS; GH SECRETAGOGUE; NEUROPEPTIDE-Y; MESSENGER-RNA; RECEPTOR; NEURONS; EXPRESSION; SECRETION; PITUITARY;
Keywords:
hypothalamus; arcuate nucleus; supraoptic nucleus; oxytocin; vasopressin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bailey, ART Ctr Reprod Biol, Edinburgh EH3 9ET, Midlothian, Scotland Ctr Reprod Biol Edinburgh Midlothian Scotland EH3 9ET cotland
Citazione:
A.R.T. Bailey et al., "Central actions of the nonpeptide growth hormone secretagogue GHS-25", ENDOCRINE, 14(1), 2001, pp. 15-19

Abstract

Growth hormone secretagogues (GHSs) increase the activity of hypothalamic arcuate nucleus neurons thought to be involved in controlling the release of growth hormone (GH). The GHS receptor is also found in hypothalamic regions not associated with the release of CH, suggesting that GHSs may influence other hypothalamic systems. This study utilized double-labeling immunocytochemical techniques to examine the hypothalamic actions of a novel nonpeptide CHS, GHS-25, In common with other GHSs, GHS-25 induced significant amounts of Fos immunoreactivity in the arcuate nucleus of conscious male rats. However, unlike other CHSs, GHS-25 also induced Fos immunoreactivity in thesupraoptic nucleus. Double labeling revealed that approx 66% of supraopticnucleus cells that were Fos positive after the administration of GHS-25 were also immunoreactive for oxytocin, Thus, in addition to its actions on the GH axis, GHS-25 may influence the release of neurohypophyseal hormone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:24:09