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Titolo:
Glycolysis as a target for the design of new anti-trypanosome drugs
Autore:
Verlinde, CLM; Hannaert, V; Blonski, C; Willson, M; Perie, JJ; Fothergill-Gilmore, LA; Opperdoes, FR; Gelb, MH; Hol, WGJ; Michels, PAM;
Indirizzi:
Univ Washington, Biomol Struct Ctr, Dept Biol Struct, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Biol Struct, Seattle, WA 98195 USA Univ Catholique Louvain, Christian de Duve Inst Cellular Pathol, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Biochem Lab, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Toulouse 3, Grp Chim Organ Biol, CNRS, UMR 5068, F-31062 Toulouse, France Univ Toulouse 3 Toulouse France F-31062 R 5068, F-31062 Toulouse, France Univ Edinburgh, Dept Biomed Sci, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Univ Washington, Dept Chem, Seattle, WA 98195 USA Univ Washington SeattleWA USA 98195 on, Dept Chem, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biochem, Seattle, WA 98195 USA Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA USA Univ Washington Seattle WA USA , Howard Hughes Med Inst, Seattle, WA USA
Titolo Testata:
DRUG RESISTANCE UPDATES
fascicolo: 1, volume: 4, anno: 2001,
pagine: 50 - 65
SICI:
1368-7646(200102)4:1<50:GAATFT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; BLOOD-STREAM FORM; LEISHMANIA-MEXICANA MEXICANA; AUTOCRINE MOTILITY FACTOR; RABBIT MUSCLE ALDOLASE; CRYSTAL-STRUCTURE; TRIOSEPHOSPHATE ISOMERASE; PYRUVATE-KINASE; PHOSPHOGLYCERATE KINASE; ESCHERICHIA-COLI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Michels, PAM ICP TROP 74 39, Ave Hippocrate 74, B-1200 Brussels, Belgium ICP TROP 74 39 Ave Hippocrate 74 Brussels Belgium B-1200 ium
Citazione:
C.L.M. Verlinde et al., "Glycolysis as a target for the design of new anti-trypanosome drugs", DRUG RESIST, 4(1), 2001, pp. 50-65

Abstract

Glycolysis is perceived as a promising target for new drugs against parasitic trypanosomatid protozoa because this pathway plays an essential role intheir ATP supply, Trypanosomatid glycolysis is unique in that it is compartmentalized, and many of its enzymes display unique structural and kinetic features. Structure- and catalytic mechanism-based approaches are applied to design compounds that inhibit the glycolytic enzymes of the parasites without affecting the corresponding proteins of the human host. For some trypanosomatid enzymes, potent and selective inhibitors have already been developed that affect only the growth of cultured trypanosomatids, and not mammalian cells. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:54:11