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Titolo:
Significance of histiocytes in cervical smears from peri/postmenopausal women
Autore:
Tambouret, R; Bell, DA; Centeno, BA;
Indirizzi:
Harvard Univ, Dept Pathol, Sch Med, Massachusetts Gen Hosp,James Homer Wright Labs, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Homer Wright Labs, Boston, MA 02114 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 271 - 275
SICI:
8755-1039(200104)24:4<271:SOHICS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL ADENOCARCINOMA;
Keywords:
histiocytes; postmenopausal; perimenopausal; cervical smears; vaginal smears; endometrial neoplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Tambouret, R Harvard Univ, Dept Pathol, Sch Med, Massachusetts Gen Hosp,James Homer Wright Labs, 55 Fruit St, Boston, MA 02114 USA Harvard Univ 55 Fruit St Boston MA USA 02114 on, MA 02114 USA
Citazione:
R. Tambouret et al., "Significance of histiocytes in cervical smears from peri/postmenopausal women", DIAGN CYTOP, 24(4), 2001, pp. 271-275

Abstract

Histiocytes in cervicovaginal smears from peri- or postmenopausal women have been viewed as a potential indicator of endometrial neoplasia, but recent studies have refuted that view. This study further defines the clinical significance of such findings. All cervical smears were selected from women (greater than or equal to 50 yr) in whom the presence of histiocytes was mentioned; pertinent clinical history, follow-up information, and selected slides were reviewed. Among 105,225 total cervicovaginal smears from a 3.5-yrperiod, 106 smears from 103 women were identified. Forty-two patients (41%) were on hormone replacement therapy (2 on tamoxifen), and 23 (22.3%) patients experienced vaginal bleeding, all of whom had biopsy or cytology follow-up. Ten (9.6%) patients had no follow-up, 35 (32%) had repeat smears only, and 58 (56.3%) had endometrial/endocervical sampling. In 28 patients, theindex smear was categorized as other than within normal limits or benign cellular changes; of these, 24 had subsequent tissue sampling and 4 had cytology follow-up. Of the patients with tissue sampling, 51 (84%) had benign findings (including polyps), 2 (3.5%) had hyperplasia, and 5 (10%) had adenocarcinoma. All 5 patients with adenocarcinoma had endometrial glandular cells on the smear, and 4 had vaginal bleeding. One patient with hyperplasia had vaginal bleeding, and the other was on tamoxifen and had endometrial glandular cells on the smear. None of the patients having only histiocytes on their smears and no clinical symptoms or risk factors had endometrial adenocarcinoma or hyperplasia. These findings support the conclusion that the presence of histiocytes alone on cervicovaginal smears from peri- or postmenopausal women is nonspecific and of no major clinical significance in the absence of other clinical or cytologic findings. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:30:02