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Titolo:
Mechanism of transcription initiation and promoter escape by RNA polymerase II
Autore:
Dvir, A; Conaway, JW; Conaway, RC;
Indirizzi:
Oklahoma Med Res Fdn, Program Mol & Cell Biol, Oklahoma City, OK 73104 USAOklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA Oakland Univ Rochester MI USA 48309 ept Biol Sci, Rochester, MI 48309 USA Oklahoma Med Res Fdn, Howard Hughes Med Inst, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA Univ Oklahoma Oklahoma City OK USA 73190 iol, Oklahoma City, OK 73190 USA
Titolo Testata:
CURRENT OPINION IN GENETICS & DEVELOPMENT
fascicolo: 2, volume: 11, anno: 2001,
pagine: 209 - 214
SICI:
0959-437X(200104)11:2<209:MOTIAP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING DOMAIN; CRYSTAL-STRUCTURE; PREINITIATION COMPLEX; MINOR-GROOVE; TATA-ELEMENT; CORE DOMAIN; TFIIH; ATP; HELICASE; UPSTREAM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Conaway, JW Oklahoma Med Res Fdn, Program Mol & Cell Biol, 825 Ne 13Th St,Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn 825 Ne 13Th St Oklahoma City OK USA 73104
Citazione:
A. Dvir et al., "Mechanism of transcription initiation and promoter escape by RNA polymerase II", CUR OP GEN, 11(2), 2001, pp. 209-214

Abstract

Recently, key advances in biochemical and structural studies of RNA polymerase II (pol II) and the basal transcriptional machinery have shed considerable light on the basic mechanisms underlying the initiation stage of eukaryotic mRNA synthesis. The development of methods for obtaining crystal structures of pot II and its complexes has revolutionized transcriptional studies and holds promise that aspects of initiation will soon be understood at atomic resolution; crosslinking studies have revealed intriguing features of the topology of the pot II initiation complex and provided working modelsfor dynamic steps of initiation; and mechanistic studies have identified promoter escape as a critical step during initiation and brought to light novel roles for the general initiation factors TFIIE, TFIIF, and TFIIH in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:30:38