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Titolo:
Pathological findings in cumulative irritation induced by SLS and croton oil in hairless mice
Autore:
Moon, SH; Il Seo, K; Han, WS; Suh, DH; Cho, KH; Kim, JJ; Eun, HC;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Dermatol, Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Gu, Seoul 110744, South Korea LG Chem Ltd, Cosmet R&D Ctr, Daejeon, South Korea LG Chem Ltd Daejeon South Korea d, Cosmet R&D Ctr, Daejeon, South Korea
Titolo Testata:
CONTACT DERMATITIS
fascicolo: 4, volume: 44, anno: 2001,
pagine: 240 - 245
SICI:
0105-1873(200104)44:4<240:PFICII>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN; IRRITANTS;
Keywords:
irritant contact dermatitis; chronic; histopathology; SLS; croton oil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Eun, HC Seoul Natl Univ, Coll Med, Dept Dermatol, Chongno Gu, 28 Yungon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yungon Dong Seoul South Korea 110744 uth Korea
Citazione:
S.H. Moon et al., "Pathological findings in cumulative irritation induced by SLS and croton oil in hairless mice", CONTACT DER, 44(4), 2001, pp. 240-245

Abstract

It is known that the pathological features of acute irritant contact dermatitis are specific according to the irritant. However, in chronic irritant contact dermatitis. it is not clear whether specific patterns exist. To investigate whether the specific pathology of acute irritant contact dermatitis is sustained in chronic irritant contact dermatitis. sodium lauryl sulfate (SLS) and croton oil were applied 3x a week for 2 weeks on the dorsal skin of hairless mice using Finn Chambers. The pathologic changes induced by irritants at various concentrations were evaluated using H&E and Luna's staining, as well as immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU), keratin 6 and loricrin. Our results showed that epidermal hyperplasia and inflammatory infiltration were relatively marked in the groups treated with higher concentrations of irritants. These features were more prominent in the1% croton oil treated group than in the 0.25% SLS treated group. However, lower concentrations of irritants resulted in very similar histological changes, characterized by epidermal hyperplasia with minimal inflammatory infiltration, irrespective of the chemical. Our results suggest that the histological responses to irritants vary with concentration in cumulative irritation, as in acute irritation, but repetitive mild irritation may evoke common histological changes, characterized by epidermal hyperplasia with minimalinflammatory infiltration, irrespective of the chemical used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:50:46