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Titolo:
Chemical network of the living human brain - Evidence of reorganization with aging
Autore:
Grachev, ID; Apkarian, AV;
Indirizzi:
SUNY Upstate Med Univ, Dept Radiol, Syracuse, NY 13210 USA SUNY Upstate Med Univ Syracuse NY USA 13210 adiol, Syracuse, NY 13210 USA SUNY Upstate Med Univ, Dept Neurosurg, Syracuse, NY 13210 USA SUNY UpstateMed Univ Syracuse NY USA 13210 osurg, Syracuse, NY 13210 USA SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA SUNY Upstate Med Univ Syracuse NY USA 13210 ysiol, Syracuse, NY 13210 USA Northwestern Univ, Sch Med, Dept Physiol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 ept Physiol, Chicago, IL 60611 USA
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 2, volume: 11, anno: 2001,
pagine: 185 - 197
SICI:
0926-6410(200104)11:2<185:CNOTLH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; PROTON MR SPECTROSCOPY; PRIMARY SOMATOSENSORY CORTEX; IN-VIVO; ALZHEIMERS-DISEASE; CORTICAL REORGANIZATION; AUDITORY-CORTEX; SEX-DIFFERENCES; ADULT MONKEYS; GRAY-MATTER;
Keywords:
aging; brain chemistry; chemical network; reorganization; proton MR spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Grachev, ID SUNY Upstate Med Univ, Dept Radiol, 750 E Adams St,IHP 4109, Syracuse, NY 13210 USA SUNY Upstate Med Univ 750 E Adams St,IHP 4109 Syracuse NY USA 13210
Citazione:
I.D. Grachev e A.V. Apkarian, "Chemical network of the living human brain - Evidence of reorganization with aging", COGN BRAIN, 11(2), 2001, pp. 185-197

Abstract

We recently described the chemical network properties of the human brain using in vivo proton magnetic resonance spectroscopy (H-1 MRS). In a separate study of aging we found increased concentration of chemicals in the prefrontal and sensorimotor cortices up to the third decade of life, and subsequent decrease of chemical concentrations in the same brain regions after thethird decade between young and middle age. We anticipated that these age-dependent differences in chemical concentrations might be a reflection of the chemical network reorganization of the brain during aging. The pattern ofchemical connectivity within and across brain regions for all regional chemicals, and specific patterns of chemical connectivity for each chemical type were examined for young and middle age groups using H-1 MRS and correlation analysis. For all studied ages, the dominant positive correlations occurred within brain regions and negative correlations were seen across brain regions. However, the pattern of negative chemical connectivity across brain regions was weaker in middle-aged group (F=40.4, P<10(-7) comparing r-values between the two age groups, ANOVA). Within brain regions, the age effects on chemical correlations were seen in the cingulate cortex (46% decreasein the middle-aged group, F=7.2, P<0.007) and sensorimotor cortex (SMC) (27% decrease, F=8.9, P<0.003). Between brain regions, the age effects on chemical correlations were seen in the chemical interactions between the thalamus (433.3% increase in the middle-aged group, F=11.7, P<0.003), SMC (280% increase, F=20.1, P<10(-5)), cingulate cortex (100.7% increase, F=21.3, P<10(-7)), and other brain regions. We found also age-differential patterns ofchemical connectivity across the studied brain regions for most chemical types. The results provide evidence that normal aging is associated with reorganization of chemical network of the human brain. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:48:42