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Titolo:
Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia
Autore:
Hirayama, A; Okoshi, Y; Hachiya, Y; Ozawa, Y; Ito, M; Kida, Y; Imai, Y; Kohsaka, S; Takashima, S;
Indirizzi:
Natl Ctr Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorder, Dept Clin Lab, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat Tokyo Japan 1878502 Lab, Tokyo 1878502, Japan Matsudo Municipal Hosp, Dept Neomatal, Tokyo, Japan Matsudo Municipal Hosp Tokyo Japan al Hosp, Dept Neomatal, Tokyo, Japan Natl Inst Neurosci, Dept Mental Retardat & Birth Defect Res, Tokyo, Japan Natl Inst Neurosci Tokyo Japan etardat & Birth Defect Res, Tokyo, Japan Natl Inst Neurosci, Dept Neurochem, Tokyo, Japan Natl Inst Neurosci Tokyo Japan t Neurosci, Dept Neurochem, Tokyo, Japan NCNP, Natl Inst Neurosci, Tokyo, Japan NCNP Tokyo JapanNCNP, Natl Inst Neurosci, Tokyo, Japan
Titolo Testata:
CLINICAL NEUROPATHOLOGY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 87 - 91
SICI:
0722-5091(200103/04)20:2<87:EIDOAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN;
Keywords:
extremely low birth weight; beta-amyloid precursor protein; ionized calcium-binding adaptor molecule 1; glial fibrillary acidic protein; periventricular leukomalacia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hirayama, A Natl Ctr Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorder, Dept Clin Lab, 4-1-1 Ogawahigashi, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat 4-1-1 Ogawahigashi Tokyo Japan 1878502
Citazione:
A. Hirayama et al., "Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia", CLIN NEUR, 20(2), 2001, pp. 87-91

Abstract

Extremely low birth weight (ELBW) infants, who died at 12 hours to 7 days after birth, with periventricular leukomalacia (PVL), were examined by means of neuropathological and immunohistochemical methods. Fourteen infants without PVL were used as controls. Anti-beta -amyloid precursor protein (APP), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (Iba1) antibodies were used as markers for axonal damage, reactive astrocytes and activated microglia, respectively. Thirteen of 14 ELBWinfants with PVL showed a widespread distribution of leukomalacia and 10 showed postnatal-onset of leukomalacia. In 12 of the 14 infants with PVL, regions of APP-reactive axons were found multifocally in the cerebral white matter, but 8 of them did not show coagulation necrosis on HE staining. GFAP-positive cells and Iba1-positive cells were markedly found in the white matter of all cases with PVL and slightly in all 14 controls. These results indicated that in ELBW infants, the distribution and formation of PVL foci are widespread and characteristic and so may involve motor and intellectual abilities in ELBW infants. Therefore, the perinatal management to maintain an appropriate cerebral circulation and oxygenation may be very important.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:34:00