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Titolo:
Serum lactate dehydrogenase isoenzyme 1 and prediction of death in patients with metastatic testicular germ cell tumors
Autore:
von Eyben, FE; Blaabjerg, O; Hyltoft-Petersen, P; Madsen, EL; Amato, R; Liu, F; Fritsche, H;
Indirizzi:
Odense Univ Hosp, Dept Clin Chem, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 in Chem, DK-5000 Odense, Denmark Soenderborg Hosp, Dept Oncol, Soenderborg, Denmark Soenderborg Hosp Soenderborg Denmark , Dept Oncol, Soenderborg, Denmark Univ Texas, MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 ourinary Med Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Lab Med, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Dept Lab Med, Houston, TX 77030 USA
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 1, volume: 39, anno: 2001,
pagine: 38 - 44
SICI:
1434-6621(200101)39:1<38:SLDI1A>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER;
Keywords:
lactate dehydrogenase isoenzymes; testicular neoplasms; alpha-fetoproteins; human chorionic gonadotropin; predictive value of a test; metaanalysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: von Eyben, FE Gaerdesmuttevej 30, DK-5210 Odense NV, Denmark Gaerdesmuttevej 30 Odense Denmark NV 10 Odense NV, Denmark
Citazione:
F.E. von Eyben et al., "Serum lactate dehydrogenase isoenzyme 1 and prediction of death in patients with metastatic testicular germ cell tumors", CLIN CH L M, 39(1), 2001, pp. 38-44

Abstract

The International Germ Cell Cancer Collaborative Group study of patients with metastatic testicular germ cell tumors showed that catalytic concentration of serum lactate dehydrogenase (S-LD), serum alpha -fetoprotein concentration (S-AFP), and serum human chorionic gonadotropin concentration (S-AFP) predicted death from tumor. The recent international TNM classification (T primary tumor, N lymph node metastasis, M distant metastasis) is based onthese results. The aim of our study was to evaluate whether catalytic concentration of S-LD isoenzyme 1 (S-LD-1) was a better predictor than the criteria used for the international classification. In an evaluation series of 44 patients from Odense University Hospital, Denmark, a raised S-LD-1 (>1.0x upper limit of reference values) had a predictive value for death from tumor in 6-years observation of 46%. The predictive value was 46% for S-LD, 25% for S-AFP, and 40% for S-hCG. A normal S-LD-1 had a predictive value for survival over 5-years observation of 100%. it was 81% for S-LD, 75% for S-AFP, and 77% for S-hCG. The fraction of the patients who died of tumor andhad a raised tumor marker value was 100% for S-LD-1, 46% for S-LD, 9% for S-AFP, and 18% for S-hCG. The fraction of patients with a normal serum tumor marker value among those who survived was 61% for S-LD-1, 81% for S-LD, 94% for S-AFP, and 94% for S-hCG. A validation series of 37 patients treatedat the University of Texas MD Anderson Cancer Center showed similar findings. Combining the patients in the two series, a raised value of S-LD-1 classified more patients into a subgroup with an impaired survival (53%) than S-LD (35%), S-AFP (6%), or S-hCG (11%), and the high risk subgroups based onthe international classification (40%). The findings have implications forthe staging and treatment of patients with metastatic testicular germ celltumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:42:53