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Titolo:
Photodynamic therapy in the canine prostate using motexafin lutetium
Autore:
Hsi, RA; Kapatkin, A; Strandberg, J; Zhu, T; Vulcan, T; Solonenko, M; Rodriguez, C; Chang, J; Saunders, M; Mason, N; Hahn, S;
Indirizzi:
Virginia Mason Med Ctr, Dept Radiat Oncol, Seattle, WA 98101 USA Virginia Mason Med Ctr Seattle WA USA 98101 Oncol, Seattle, WA 98101 USA Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Clin Studies, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 n Studies, Philadelphia, PA 19104 USA Johns Hopkins Univ, Sch Med, Div Comparat Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 at Med, Baltimore, MD 21205 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 3, volume: 7, anno: 2001,
pagine: 651 - 660
SICI:
1078-0432(200103)7:3<651:PTITCP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-AMINOLEVULINIC ACID; TEXAPHYRIN PCI-0123; CANCER; MANAGEMENT; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hsi, RA Virginia Mason Med Ctr, Dept Radiat Oncol, 1100 9th Ave,CB-RO, Seattle, WA98101 USA Virginia Mason Med Ctr 1100 9th Ave,CB-RO Seattle WA USA 98101 USA
Citazione:
R.A. Hsi et al., "Photodynamic therapy in the canine prostate using motexafin lutetium", CLIN CANC R, 7(3), 2001, pp. 651-660

Abstract

Our purpose was to determine the feasibility of comprehensive treatment ofthe canine prostate with photodynamic therapy (PDT) using motexafin lutetium (Lu-Tex) and to evaluate the toxicity and tissue effects associated withthis treatment. Twenty-five adult male beagles with normal prostate glandswere given an i.v. injection of the second-generation photosensitizer Lu-Tex (2-6 mg/kg), An additional two dogs were used as controls and did not receive any photosensitizing drug. All 27 dogs underwent laparotomy to exposethe prostate. Three hours postinjection, a total dose of 75-150 J/cm of 732 nm laser light was delivered interstitially and/or transurethrally to theprostate via cylindrical diffusing fibers. Dogs were euthanized between 2 days and 3 months after PDT, All subjects were monitored for clinical evidence of toxicity. Specimens were examined macroscopically and microscopically to characterize the tissue reaction and assess extent of tissue effect asa result of treatment. Interstitial and/or transurethral PDT were successfully delivered in all dogs with no perioperative complications. No clinicalevidence of acute urinary obstruction or rectal bleeding was noted. At alldose levels, macroscopic and microscopic evaluation revealed a prostatic tissue reaction characterized initially (within 48 h) by inflammation and necrosis followed by fibrosis and glandular epithelial atrophy. Comprehensivetreatment of the entire prostate could be achieved using the interstitial alone approach or combined transurethral and interstitial approach. The transurethral alone approach did not result in complete coverage of the prostate. Dogs receiving transurethral or combined interstitial and transurethraltreatment developed erythema and urethral epithelial disruption at all dose levels. Those receiving combined treatment at the highest dose level (Lu-Tex 6 mg/kg, 150 J/cm light) developed urethral fistulae and peritonitis. Dogs treated with the interstitial alone approach were found to have the least amount of urethral damage, Comprehensive treatment of the canine prostate with Lu-Tex PDT is feasible using an interstitial alone or combined interstitial and transurethral approach. The interstitial alone technique results in the least amount of toxicity. The prostatic tissue reaction to treatment is characterized by initial inflammation and necrosis followed by fibrosis and glandular epithelial atrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:01:48