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Titolo:
Detection of p53 gene mutations in human esophageal squamous cell carcinomas using a p53 yeast functional assay: Possible difference in esophageal carcinogenesis between the young and the elderly group
Autore:
Okuda, E; Osugi, H; Morimura, K; Takada, N; Takemura, M; Fukushima, S; Higashino, M; Kinoshita, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Surg 2, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 rg 2, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Pathol, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 d, Dept Pathol, Osaka 5458585, Japan Osaka City Gen Hosp, Dept Gastrointestinal Surg, Osaka 5340021, Japan Osaka City Gen Hosp Osaka Japan 5340021 tinal Surg, Osaka 5340021, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 3, volume: 7, anno: 2001,
pagine: 600 - 606
SICI:
1078-0432(200103)7:3<600:DOPGMI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AERODIGESTIVE TRACT; HIGH-FREQUENCY; LUNG-CANCER; CHINA; PREVALENCE; EXPRESSION; SMOKING; TUMORS; RISK; HEAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Okuda, E Osaka City Univ, Sch Med, Dept Surg 2, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahi Machi Osaka Japan 5458585 585, Japan
Citazione:
E. Okuda et al., "Detection of p53 gene mutations in human esophageal squamous cell carcinomas using a p53 yeast functional assay: Possible difference in esophageal carcinogenesis between the young and the elderly group", CLIN CANC R, 7(3), 2001, pp. 600-606

Abstract

A p53 yeast functional assay, which cannot only detect p53 gene mutations but also can assess p53 gene function, was used to screen for p53 gene dysfunction in human esophageal squamous cell carcinomas, Surgically resected frozen tissues of esophageal squamous cell carcinomas from 57 patients were examined for p53 gene mutation. Because the mean age of the patients diagnosed with esophageal squamous cell carcinoma was 64 years, we classified those who were <65 Sears of age as the Young Group and classified the others as the Elderly Group. The incidence of p53 gene mutations was 43 of 57 (75%), The incidence of p53 gene mutations observed in the Young Group was significantly higher than in the Elderly Group (P = 0.0007), Alcohol and smokingstatus did not relate to p53 gene mutation expression, Survival rate aftersurgery was not significantly associated with the presence of p53 gene mutation, However, in the Young Group with p53 gene mutation, those who had null mutations had a significantly shorter survival than those without null mutations (P = 0.0455). No other clinicopathological factors were associatedwith p53 gene mutations. Possibly, there may be a difference in esophagealcarcinogenesis between the Young and the Elderly groups, because the incidence of p53 gene mutations is different between the two groups. In the Young Group, p53 gene mutation may cause esophageal carcinogenesis, and null mutation for p53 gene is a significant prognostic factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:50:15