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Titolo:
The prognostic value of molecular marker analysis in patients treated withtrimodality therapy for esophageal cancer
Autore:
Harpole, DH; Moore, MB; Herndon, JE; Aloia, T; DAmico, TA; Sporn, T; Parr, A; Linoila, I; Allegra, C;
Indirizzi:
Duke Univ, Med Ctr, Thorac Oncol Program, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Thorac Oncol Program, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Div Canc Biostat, Durham, NC27710 USA Duke Univ Durham NC USA 27710 Ctr, Div Canc Biostat, Durham, NC27710 USA NCI, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 3, volume: 7, anno: 2001,
pagine: 562 - 569
SICI:
1078-0432(200103)7:3<562:TPVOMM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA MISMATCH REPAIR; THYMIDYLATE SYNTHASE; CISPLATIN RESISTANCE; COLORECTAL-CANCER; EXPRESSION; CARCINOMA; CHEMORADIOTHERAPY; ADENOCARCINOMA; CHEMOTHERAPY; SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Harpole, DH Duke Univ, Med Ctr, Thorac Oncol Program, DUMC Box 3617, Durham, NC 27710 USA Duke Univ DUMC Box 3617 Durham NC USA 27710 rham, NC 27710 USA
Citazione:
D.H. Harpole et al., "The prognostic value of molecular marker analysis in patients treated withtrimodality therapy for esophageal cancer", CLIN CANC R, 7(3), 2001, pp. 562-569

Abstract

The purpose of this study was to define the prognostic value of a group ofmolecular tumor markers in a well-staged population of patients treated with trimodality therapy for esophageal cancer. The original pretreatment paraffin-embedded endoscopic esophageal tumor biopsy material was obtained from 118 patients treated with concurrent cisplatin + 5-fluorouracil (5-FU) + 45 Gy radiation followed by resection from 1986 until 1997 at the Duke University Comprehensive Cancer Center. Three markers of possible platinum chemotherapy association [metallothionein (MT), glutathione S-transferase-pi (GST-pi), P-glycoprotein (P-gp or multidrug resistance)] and one marker of possible 5-FU association [thymidylate synthase (TS)] were measured using immunohistochemistry. The median cancer-free survival was 25.0 months, with a significantly improved survival for the 38 patients who had a complete response (P < 0.001), High-level expression of GST-<pi>, P-gp, and TS were associated with a decreased survival. MT was not significant in this population, Multivariate analysis identified high-level expression in two of the platinum markers (GST-pi and P-gp) and the 5-FU marker TS as independent predictors of early recurrence and death, In conclusion, this investigation measured three possible markers associated with platinum and one possible markerassociated with 5-FU in a cohort of esophageal cancer patients. Independent prognostic significance was observed, which suggests that it may be possible to predict which patients may benefit most from trimodality therapy. These data heed to he reproduced in a prospective investigation.

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Documento generato il 03/07/20 alle ore 23:05:42