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Titolo:
Are basic fibroblast growth factor and vascular endothelial growth factor prognostic indicators in pediatric patients with malignant solid tumors?
Autore:
Tabone, MD; Landman-Parker, J; Arcil, B; Coudert, MC; Gerota, I; Benbunan, M; Leverger, G; Bosquet, C;
Indirizzi:
Hop Enfant Armand Trousseau, Serv Hematol & Oncol Pediat, F-75012 Paris, France Hop Enfant Armand Trousseau Paris France F-75012 , F-75012 Paris, France Ctr Bilans Sante Enfant, F-75011 Paris, France Ctr Bilans Sante Enfant Paris France F-75011 fant, F-75011 Paris, France Hop St Louis, Unite Therapie Cellulaire, F-75010 Paris, France Hop St Louis Paris France F-75010 apie Cellulaire, F-75010 Paris, France
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 3, volume: 7, anno: 2001,
pagine: 538 - 543
SICI:
1078-0432(200103)7:3<538:ABFGFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOGENESIS INHIBITOR TNP-470; RENAL-CELL CARCINOMA; SERUM VEGF LEVELS; CANCER-PATIENTS; BREAST-CANCER; HUMAN NEUROBLASTOMA; METASTATIC DISEASE; GASTRIC-CARCINOMA; FACTOR EXPRESSION; BLOOD-PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Tabone, MD Hop Enfant Armand Trousseau, Serv Hematol & Oncol Pediat, 26 Ave Docteur Arnold Netter, F-75012 Paris, France Hop Enfant Armand Trousseau 26 Ave Docteur Arnold Netter Paris France F-75012
Citazione:
M.D. Tabone et al., "Are basic fibroblast growth factor and vascular endothelial growth factor prognostic indicators in pediatric patients with malignant solid tumors?", CLIN CANC R, 7(3), 2001, pp. 538-543

Abstract

Angiogenesis plays an important role in the growth, progression, and metastasis of solid tumors. Among angiogenic factors, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) appear to be useful markers in adults with cancer. The aim of this pilot study was to determine the levels of VEGF in serum and bFGF in serum and urine of children with solid tumor at diagnosis las measured by ELISA), and to investigate whether these parameters provide prognostic information. Forty consecutive patients with different types of canter were prospectively included in this study. Median values of all studied angiogenic factors were higher in patients than in controls (n = 40), and the differences were statistically significant for bFGF in serum and urine: 10 versus 3 pg/ml (P = 0.0008 and 6406 versus 0 pg/g of creatinine (P < 0.0001), respectively. Among patients, median serum values of bFGF. and VEGF were higher in children with metastatic disease (n = 14) than in those with localized disease (n = 26), The difference was statistically significant for serum bFGF: 17.5 versus 6 pg/ml (P = 0.02), Serum angiogenic factor levels correlated with outcome. The estimated event-free survival at 3 years was 79% for patients with normal bFGF values (n = 13) versus 42% (n = 26; P = 0.02) for those with high levels, and 71% in case of normal VE:GF values (n = 20) versus 38% (n = 19; P = 0.04) for those with high levels. No benefit of normal urinary bFGF values was observed. Our results provide a rationale for exploring the clinical interest of bFGF and VEGF measurements in body fluids of a larger group of children with cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:44:09