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Titolo:
Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy
Autore:
Saarinen, KM; Suomalainen, H; Savilahti, E;
Indirizzi:
Univ Helsinki, Hosp Children & Adolescents, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ts, FIN-00029 Helsinki, Finland Univ Helsinki, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland Univ Helsinki Helsinki Finland , Skin & Allergy Hosp, Helsinki, Finland
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 423 - 429
SICI:
0954-7894(200103)31:3<423:DVOSAP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOPIC-DERMATITIS; FOOD CHALLENGES; DOUBLE-BLIND; CHILDREN; ASTHMA; HYPERSENSITIVITY; MANIFESTATIONS; INTOLERANCE; CHILDHOOD; PATTERNS;
Keywords:
cow's milk allergy; infant; skin-prick test; patch test; IgE; eosinophil cationic protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Saarinen, KM Univ Helsinki, Hosp Children & Adolescents, POB 280,Lastenlinnantie 11 C 29, FIN-00029 Helsinki, Finland Univ Helsinki POB 280,Lastenlinnantie 11 C 29 Helsinki Finland FIN-00029
Citazione:
K.M. Saarinen et al., "Diagnostic value of skin-prick and patch tests and serum eosinophil cationic protein and cow's milk-specific IgE in infants with cow's milk allergy", CLIN EXP AL, 31(3), 2001, pp. 423-429

Abstract

Background The diagnosis of cow's milk allergy is based on a clinical response to an elimination-challenge test with cow's milk. Objective We studied the usefulness of the skin-prick and patch tests and measurement of cow's milk-specific IgE and eosinophil cationic protein in serum as diagnostic tools for cow's milk allergy in a cohort of 6209 unselected infants followed from birth for the development of cow's milk allergy. Results Of the 239 infants challenged with cow's milk, 118 showed a positive and 121 a negative response at a mean age of 6.9 months. A positive reaction to a skin-prick test with cow's milk (greater than or equal to 3 mm) was seen in 72 (61%) and 29 (24%) infants with positive and negative challenges, elevated serum cow's milk-specific IgE (greater than or equal to 0.7 kU/L) in 52 (45%) and 15 (13%) infants, a positive reaction to patch test with cow's milk protein fractions in 26 (26%) and eight (8%) infants, and elevated serum eosinophil cationic protein (greater than or equal to 20 mug/L)in 22 (21%) and seven (13%) infants, respectively. Parallel use of the four tests with the above-mentioned cut-off values correctly classified 73% ofthe infants with a sensitivity of 0.76 and a specificity of 0.67. An immediate reaction to cow's milk challenge correlated with skin prick test positivity and elevated serum milk-specific IgE, and tended to correlate with patch test positivity. Conclusions No single test or parallel use of the four tests could predictthe challenge outcome acceptably in this prospectively followed, unselected cohort of 6209 infants. A positive reaction to one or more tests needs tobe confirmed by a challenge test and a negative response to all four testsdoes not rule out the possibility of cow's milk allergy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:41:01