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Titolo:
Relation between exhaled carbon monoxide levels and clinical severity of asthma
Autore:
Yamaya, M; Hosoda, M; Ishizuka, S; Monma, M; Matsui, T; Suzuki, T; Sekizawa, K; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Univ Tsukuba, Inst Clin Med, Dept Pulm Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 m Med, Tsukuba, Ibaraki 305, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 417 - 422
SICI:
0954-7894(200103)31:3<417:RBECML>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEME OXYGENASE-1; OXIDATIVE STRESS; AIR; INFLAMMATION; GLUCOCORTICOIDS; MACROPHAGES; NICOTINE; COTININE; DISEASE; MARKER;
Keywords:
heme oxygenase; nitric oxide; airway inflammation; carbon monoxide; asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Tohoku Univ, Sch Med, Dept Geriatr & Resp Med, Aoba Ku, Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ Seiryo Machi Sendai Miyagi Japan 9808574 8574, Japan
Citazione:
M. Yamaya et al., "Relation between exhaled carbon monoxide levels and clinical severity of asthma", CLIN EXP AL, 31(3), 2001, pp. 417-422

Abstract

Background Carbon monoxide (CO) can be detected in exhaled air and is increased in asthmatic patients not treated with corticosteroids. However, it is uncertain whether exhaled CO is related to severity of asthma. Objective and methods To study whether exhaled CO is related to severity of asthma in clinical courses, exhaled CO concentrations were measured on a CO monitor by vital capacity manoeuvre in 20 mild asthmatics treated with inhaled beta2-agonists alone, 20 moderate asthmatics treated with inhaled corticosteroids, and 15 stable asthmatics treated with high dose inhaled corticosteroids and oral corticosteroids once a month over 1 years. Exhaled CO concentrations were also measured in 16 unstable severe asthmatics who visited the hospital every 7 or 14 days for treatment with high dose inhaled corticosteroids and oral corticosteroids. Results The mean values of exhaled CO in severe asthma over 1 year were 6.7 +/- 9.5 p.p.m. (n = 31, mean +/- SD) and significantly higher than those of non-smoking control subjects (1.2 +/- 0.9 p.p.m., n = 20, P < 0.01). Exhaled CO concentrations in unstable severe asthmatics were significantly higher than those in stable severe asthmatics. However, exhaled CO concentrations in mild and moderate asthmatics did not differ significantly from thosein non-smoking control subjects (P > 0.20). There was a significant relationship between the exhaled CO concentrations and forced expiratory volume in one second in all asthmatic patients. Conclusion These findings suggest that exhaled CO concentrations may relate to the severity of asthma and measurements of exhaled CO concentrations may be a useful means of monitoring airway inflammation in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:35:48