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Titolo:
Carbon-detected NMR experiments to investigate structure and dynamics of biological macromolecules
Autore:
Serber, Z; Richter, C; Dotsch, V;
Indirizzi:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Grad Grp Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Bruker AG, CH-8117 Fallanden, Switzerland Bruker AG Fallanden Switzerland CH-8117 , CH-8117 Fallanden, Switzerland
Titolo Testata:
CHEMBIOCHEM
fascicolo: 4, volume: 2, anno: 2001,
pagine: 247 - 251
SICI:
1439-4227(20010402)2:4<247:CNETIS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIPLE-RESONANCE NMR; PROTEINS; SPECTROSCOPY; C-13; BACKBONE; ASSIGNMENT; COMPLEX; H-1;
Keywords:
NMR spectroscopy; protein structures; pulse sequences; structure elucidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Dotsch, V Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 A 94143 USA
Citazione:
Z. Serber et al., "Carbon-detected NMR experiments to investigate structure and dynamics of biological macromolecules", CHEMBIOCHEM, 2(4), 2001, pp. 247-251

Abstract

We have started to develop new NMR pulse sequences that detect carbon magnetization during the acquisition period. These experiments have become possible with the recent introduction of cryogenic probe heads. We show that a careful design of these carbon-detected experiments can at least partially compensate for the inherent lower sensitivity of carbon detection compared to proton detection. We discuss potential applications of carbon defection and demonstrate a deconvolution technique that removes the effects of carbon - carbon couplings from the spectra.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:15:01