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Titolo:
CD1d and natural T cells: how their properties jump-start the immune system
Autore:
Joyce, S;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 & Immunol, Nashville, TN 37232 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 3, volume: 58, anno: 2001,
pagine: 442 - 469
SICI:
1420-682X(200103)58:3<442:CANTCH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; RECEPTOR-ALPHA-CHAIN; ANTIGEN-PRESENTING MOLECULES; IMMUNOGLOBULIN-E PRODUCTION; NONOBESE DIABETIC MICE; GLYCOSYL-PHOSPHATIDYLINOSITOL ANCHOR; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; THYMUS LEUKEMIA ANTIGEN; V(ALPHA)14 NKT CELLS; ZONE B-CELLS;
Keywords:
CD1d; glycolipid antigen; natural killer T cells; pro-inflammatory cytokines; anti-inflammatory cytokine; interleukin-4; interleukin-12; interferon-gamma; granulocyte-macrophage colony-stimulating factor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
258
Recensione:
Indirizzi per estratti:
Indirizzo: Joyce, S Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, 221 Kirkland Hall, Nashville, TN 37232 USA Vanderbilt Univ 221 Kirkland Hall Nashville TN USA 37232 7232 USA
Citazione:
S. Joyce, "CD1d and natural T cells: how their properties jump-start the immune system", CELL MOL L, 58(3), 2001, pp. 442-469

Abstract

Cellular and humoral immune mechanisms recruited to defend the host from infectious agents depend upon the early immune events triggered by antigen. The cytokine milieu within which the immune response matures is the most important of many factors that govern the nature of the immune response. Natural T cells, whose function is controlled by CD1d molecules, are an early source of cytokines that can bestow type 1 or type 2 differentiative potential upon helper T lymphocytes. This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T cells and how CD1d and natural T cells interact to jump start the immune system. CD1d is postulated to function as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates natural T cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jumpstart the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:14:19