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Titolo:
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
Autore:
Abdel-Malek, ZA;
Indirizzi:
Univ Cincinnati, Dept Dermatol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ermatol, Cincinnati, OH 45267 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 3, volume: 58, anno: 2001,
pagine: 434 - 441
SICI:
1420-682X(200103)58:3<434:MRTFAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING-HORMONE; CULTURED HUMAN MELANOCYTES; MOUSE AGOUTI GENE; MOLECULAR-CLONING; ALPHA-MSH; RED HAIR; PROOPIOMELANOCORTIN PEPTIDES; ANTIINFLAMMATORY ACTION; HUMAN KERATINOCYTES; POINT MUTATIONS;
Keywords:
melanocortin receptor; proopiomelanocortin; melanocortin; agouti signaling protein; agouti-related protein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Abdel-Malek, ZA Univ Cincinnati, Dept Dermatol, POB 670592,231 Albert Sabin Way,Room 7409,Cincinnati, OH 45267 USA Univ Cincinnati POB 670592,231 Albert Sabin Way,Room 7409 Cincinnati OH USA 45267
Citazione:
Z.A. Abdel-Malek, "Melanocortin receptors: their functions and regulation by physiological agonists and antagonists", CELL MOL L, 58(3), 2001, pp. 434-441

Abstract

The melanocortins are a family of bioactive peptides derived from proopiomelanocortin, and share significant structural similarity. Those peptides are best known for their stimulatory effects on pigmentation and steroidogenesis. Melanocortins are synthesized in various sites in the central nervous system and in peripheral tissues, and participate in regulating multiple physiological functions. Research during the past decade has provided evidence that melanocortins elicit their diverse biological effects by binding to a distinct family of G protein-coupled receptors with seven transmembrane domains. To date, five melanocortin receptor genes have been cloned and characterized. Those receptors differ in their tissue distribution and in theirability to recognize the various melanocortins and the physiological antagonists, agouti signaling protein and agouti-related protein. These advanceshave opened new horizons for exploring the significance of melanocortins, their antagonists, and their receptors in a variety of important physiological functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:50:24