Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic and molecular analysis of the synaptotagmin family
Autore:
Adolfsen, B; Littleton, JT;
Indirizzi:
MIT, Ctr Learning & Memory, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 Ctr Learning & Memory, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 3, volume: 58, anno: 2001,
pagine: 393 - 402
SICI:
1420-682X(200103)58:3<393:GAMAOT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUID GIANT SYNAPSE; MEMBRANE-FUSION; NEUROTRANSMITTER RELEASE; C2B DOMAIN; TRANSMITTER RELEASE; SNARE COMPLEX; NEURONAL-SYNAPTOBREVIN; PHOSPHOLIPID-BINDING; ANTIBODY INJECTION; CALCIUM-DEPENDENCE;
Keywords:
synaptotagmin; neurotransmitter release; exocytosis; synapse; SNARE; endocytosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Littleton, JT MIT, Ctr Learning & Memory, 50 Ames St,E-18-672, Cambridge, MA 02139 USA MIT 50 Ames St,E-18-672 Cambridge MA USA 02139 MA 02139 USA
Citazione:
B. Adolfsen e J.T. Littleton, "Genetic and molecular analysis of the synaptotagmin family", CELL MOL L, 58(3), 2001, pp. 393-402

Abstract

Secretion is a fundamental cellular process used by all eukaryotes to insert proteins into the plasma membrane and transport signaling molecules and intravesicular proteins into the extracellular space. Secretion requires the fusion of two phospholipid bilayers within the cell, an energetically unfavorable process. A conserved repertoire of vesicle-trafficking proteins has evolved that function to overcome this energy barrier and temporally and spatially control membrane fusion within the cell. Within neurons, opening of synaptic calcium channels and subsequent calcium entry triggers synchronous synaptic vesicle exocytosis and neurotransmitter release into the synaptic cleft. After fusion, synaptic Vesicles undergo endocytosis, are refilled with neurotransmitter, and return to the vesicle pool for further rounds of cycling. It is within this local synaptic trafficking pathway that the synaptotagmin family of calcium-binding synaptic vesicle proteins has been postulated to function. Here we review the current literature on the function of the synaptotagmin family and discuss the implications for synaptic transmission and membrane trafficking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 13:43:38