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Titolo:
Apoptotic and necrotic cell death induced by death domain receptors
Autore:
Denecker, G; Vercammen, D; Declercq, W; Vandenabeele, P;
Indirizzi:
Flanders Interuniv Inst Biotechnol, Dept Mol Biol, B-9000 Ghent, Belgium Flanders Interuniv Inst Biotechnol Ghent Belgium B-9000 0 Ghent, Belgium State Univ Ghent, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 Univ Ghent, B-9000 Ghent, Belgium
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 3, volume: 58, anno: 2001,
pagine: 356 - 370
SICI:
1420-682X(200103)58:3<356:AANCDI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CYTOCHROME-C RELEASE; BCL-X-L; PERMEABILITY TRANSITION PORE; DEPENDENT ANION CHANNEL; CERAMIDE-INDUCED APOPTOSIS; LOW-DENSITY LIPOPROTEINS; NITRIC-OXIDE; POLY(ADP-RIBOSE) POLYMERASE; DNA FRAGMENTATION;
Keywords:
apoptosis; necrosis; death receptor; caspase; mitochondria;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
201
Recensione:
Indirizzi per estratti:
Indirizzo: Vandenabeele, P Flanders Interuniv Inst Biotechnol, Dept Mol Biol, KL Ledeganckstr 35, B-9000 Ghent, Belgium Flanders Interuniv Inst Biotechnol KL Ledeganckstr 35 Ghent Belgium B-9000
Citazione:
G. Denecker et al., "Apoptotic and necrotic cell death induced by death domain receptors", CELL MOL L, 58(3), 2001, pp. 356-370

Abstract

Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as initiators and effecters of apoptotic cell death and are involved in many of the morphological and biochemical features of apoptosis. Major changes in mitochondrial membrane integrity and release of proapoptotic factors, such as cytochrome c from the mitochondrial intermembrane space, play an important sensor and amplifying role during apoptotic cell death. In vitro studies of cell death in cell lines have revealed that inhibition of the classical caspase-dependent apoptotic pathway leads in several cases to necrotic cell death. Thus, the same cell death stimulus can result either in apoptotic or necrotic cell death, depending on the availability of activated caspase. Therefore, death domain receptors may initiate an activecaspase-independent necrotic signaling pathway. In this review, we describe what is known about the apoptotic and necrotic cell death pathways. Principal elements of necrosis include mitochondrial oxidative phosphorylation, reactive oxygen production, and non-caspase proteolytic cascades depending on serine proteases, calpains, or cathepsins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:08:20