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Titolo:
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene
Autore:
Howell, CY; Bestor, TH; Ding, F; Latham, KE; Mertineit, C; Trasler, JM; Chaillet, JR;
Indirizzi:
Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Pediat, Pittsburgh, PA 15260 USA Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 iol Sci, Pittsburgh, PA 15260 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Temple Univ, Sch Med, Dept Biochem, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19122 USA Temple Univ Philadelphia PA USA 19122 ol Biol, Philadelphia, PA 19122 USA McGill Univ, Montreal Childrens Hosp, Res Inst, Dept Pediat, Montreal, PQ H3H 1P3, Canada McGill Univ Montreal PQ Canada H3H 1P3 diat, Montreal, PQ H3H 1P3, Canada McGill Univ, Montreal Childrens Hosp, Res Inst, Dept Human Genet, Montreal, PQ H3H 1P3, Canada McGill Univ Montreal PQ Canada H3H 1P3 enet, Montreal, PQ H3H 1P3, Canada McGill Univ, Montreal Childrens Hosp, Res Inst, Dept Pharmacol & Therapeut, Montreal, PQ H3H 1P3, Canada McGill Univ Montreal PQ Canada H3H 1P3 peut, Montreal, PQ H3H 1P3, Canada McGill Univ, Montreal Childrens Hosp, Res Inst, Dept Therapeut, Montreal, PQ H3H 1P3, Canada McGill Univ Montreal PQ Canada H3H 1P3 peut, Montreal, PQ H3H 1P3, Canada
Titolo Testata:
CELL
fascicolo: 6, volume: 104, anno: 2001,
pagine: 829 - 838
SICI:
0092-8674(20010323)104:6<829:GIDBAM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARENTAL-SPECIFIC METHYLATION; DNA METHYLTRANSFERASE GENE; MOUSE H19 GENE; PREIMPLANTATION DEVELOPMENT; PARTHENOGENETIC DEVELOPMENT; EPIGENETIC MODIFICATIONS; MAMMALIAN DEVELOPMENT; PATERNAL METHYLATION; CYTOSINE METHYLATION; OOCYTE GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Chaillet, JR Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sburgh, PA 15260 USA
Citazione:
C.Y. Howell et al., "Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene", CELL, 104(6), 2001, pp. 829-838

Abstract

Maintenance of genomic methylation patterns in mammalian somatic cells depends on DNA methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but express a variant of this protein called Dnmt1o. We eliminated Dnmt1o by deletion of the oocyte-specific promoter and first exon from the Dnmt1 locus. Homozygous animals were normal, but most heterozygous fetuses of homozygous females died during the last third of gestation. Although genomic methylation patterns were established normally in Dnmt1o-deficient oocytes, embryos derived from such oocytes showed a loss of allele-specific expression and methylation at certain imprinted loci. Transient nuclear localization of Dnmt1o in 8-cell embryos suggests that this variant of Dnmt1 provides maintenance methyltransferase activity specifically at imprinted loci during the fourth embryonic S phase.

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Documento generato il 24/09/20 alle ore 08:22:43