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Titolo:
Growth factors and stromal matrix proteins associated with mammographic densities
Autore:
Guo, YP; Martin, LJ; Hanna, W; Banerjee, D; Miller, N; Fishell, E; Khokha, R; Boyd, NF;
Indirizzi:
Ontario Canc Inst, Div Epidemiol & Stat, Toronto, ON M5G 2M9, Canada Ontario Canc Inst Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada Sunnybrook & Womens Coll Hosp, Dept Pathol, Toronto, ON M5S 1B2, Canada Sunnybrook & Womens Coll Hosp Toronto ON Canada M5S 1B2 N M5S 1B2, Canada Sunnybrook & Womens Coll Hosp, Dept Radiol, Toronto, ON M5S 1B2, Canada Sunnybrook & Womens Coll Hosp Toronto ON Canada M5S 1B2 N M5S 1B2, Canada Princess Margaret Hosp, Dept Pathol, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada Ontario Canc Inst, Div Expt Therapeut, Toronto, ON M5G 2M9, Canada OntarioCanc Inst Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 3, volume: 10, anno: 2001,
pagine: 243 - 248
SICI:
1055-9965(200103)10:3<243:GFASMP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTOLOGICAL RISK-FACTORS; BREAST-CANCER RISK; PARENCHYMAL PATTERNS; BENIGN; DIFFERENTIATION; CARCINOMA; TIMP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Boyd, NF Ontario Canc Inst, Div Epidemiol & Stat, 610 Univ Ave, Toronto, ON M5G 2M9, Canada Ontario Canc Inst 610 Univ Ave Toronto ON Canada M5G 2M9 , Canada
Citazione:
Y.P. Guo et al., "Growth factors and stromal matrix proteins associated with mammographic densities", CANC EPID B, 10(3), 2001, pp. 243-248

Abstract

Extensive radiologically dense breast tissue is associated with a marked increase in breast cancer risk. To explore the biological basis for this association, we have examined the association of growth factors and stromal matrix proteins in breast tissue with mammographic densities. Ninety-two formalin-fixed paraffin blocks of breast tissues surrounding benign lesions were obtained, half from breasts with Little or no density and half from breasts with extensive density, matched for age at biopsy. Sections were stainedfor cell nuclei, total collagen, the stromal matrix regulatory protein tissue metalloproteinase-3 (TIMP-3), and the growth factors, transforming growth factor-alpha and insulin-like growth factor (IGF-I), The area of immunoreactive staining was measured using quantitative microscopy, Breast tissue from subjects with extensive densities had a greater nuclear area (P = 0,007), as well as larger stained areas of total collagen (P = 0,003), TIMP-3 (P = 0.08), and IGF-I (P = 0.02) when compared with subjects with little breast density. Differences were greater for subjects less than 50 years of age. These data indicate that increased tissue cellularity, greater amounts of collagen, and increased IGF-I and TIMP-3 expression are found in tissue from mammographically dense breasts and suggest mechanisms that may mediate the associated increased risk of breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:24:27