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Titolo:
Squamous cell carcinoma antigen suppresses radiation-induced cell death
Autore:
Murakami, A; Suminami, Y; Hirakawa, H; Nawata, S; Numa, F; Kato, H;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Obstet & Gynecol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Onoda Municipal Hosp, Div Obstet & Gynecol, Onoda 7560088, Japan Onoda Municipal Hosp Onoda Japan 7560088 & Gynecol, Onoda 7560088, Japan
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 6, volume: 84, anno: 2001,
pagine: 851 - 858
SICI:
0007-0920(20010323)84:6<851:SCCASR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-TERMINAL KINASE; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; MEDIATED APOPTOSIS; TUMOR-ANTIGEN; CYSTEINE PROTEINASES; SIGNAL-TRANSDUCTION; JNK ACTIVATION; SCC ANTIGEN-1; MAP KINASES;
Keywords:
SCCA; apoptosis; radiation; caspase 3 activity; caspase 9; p38 MAPK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, H Yamaguchi Univ, Sch Med, Dept Obstet & Gynecol, 1-1-1 Minamikogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minamikogushi Ube Yamaguchi Japan 7558505 pan
Citazione:
A. Murakami et al., "Squamous cell carcinoma antigen suppresses radiation-induced cell death", BR J CANC, 84(6), 2001, pp. 851-858

Abstract

Previous study has demonstrated that squamous cell carcinoma antigen (SCCA) 1 attenuates apoptosis induced by TNF alpha., NK cell or anticancer drug. In this study, we have examined the effect of SCCA2, which is highly homologous to SCCA1, but has different target specificity, against radiation-induced apoptosis, together with that of SCCA1. We demonstrated that cell death induced by radiation treatment was remarkably suppressed not only in SCCA1 cDNA-transfected cells, but also in SCCA2 cDNA-transfected cells. In these transfectants, caspase 3 activity and the expression of activated caspase9 after radiation treatment were suppressed. Furthermore, the expression level of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) was suppressed compared to that of the control cells. The expression level of upstream stimulator of p38 MAPK, phosphorylated MKK3/MKK6, was also suppressed in the radiation-treated cells. Thus, both SCCA1 and SCCA2 may contribute to survival of the squamous cells from radiation-induced apoptosis by regulating p38 MAPK pathway. (C) 2001 Cancer Research Campaign http://www.bjcancer.com.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:40:44